Small amounts of maternal cells are normally transferred to the fetus throughout pregnancy. This transmission, known as maternal microchimerism (MMc), has been linked to autoimmune disorders, although its exact role remains unknown. Researchers wanted to see if MMc at birth predicted the likelihood of celiac disease (CD), a prevalent immune-mediated enteropathy that commonly manifests in childhood. In the Norwegian Mother, Father, and Child Cohort, we developed a case-control study. HLA class II typing was performed on participants to detect non inherited, nonshared maternal alleles (NIMA). Droplet digital (dd) PCR tests specific for common HLA class II NIMAs were used to quantify the amount of maternal DNA in cord blood DNA from 124 infants who subsequently had clinically diagnosed CD and 124 random controls. They used logistic regression to see if the presence of MMc was related with CD, and compared the ranks of cases and controls. MMc, for example, maternal HLA antigens that are not transmitted by the kid, was detected in 42% of cases and 43% of controls and was not related with CD. The MMc quantity ranks in cases and controls were likewise comparable. The subgroup with HLA-DQB1:0301 as their NIMA exhibited a possible relationship with MMc, with higher levels linked with CD.
MMc levels in cord blood were not linked to a higher risk of CD later in life.
