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Maternal Psychosocial Stress Associates With Increased Risk of Asthma Development in Offspring.

Maternal Psychosocial Stress Associates With Increased Risk of Asthma Development in Offspring.
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Magnus MC, Wright RJ, Røysamb E, Parr CL, Karlstad Ø, Page CM, Nafstad P, Håberg SE, London SJ, Nystad W,


Magnus MC, Wright RJ, Røysamb E, Parr CL, Karlstad Ø, Page CM, Nafstad P, Håberg SE, London SJ, Nystad W, (click to view)

Magnus MC, Wright RJ, Røysamb E, Parr CL, Karlstad Ø, Page CM, Nafstad P, Håberg SE, London SJ, Nystad W,

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American journal of epidemiology 2017 12 13() doi 10.1093/aje/kwx366
Abstract

Prenatal maternal psychosocial stress might influence childhood asthma development. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics and/or hypnotics, life satisfaction, relationship satisfaction, work stress and social support. Childhood asthma was associated with maternal lifetime major depressive symptoms, adjusted relative risk (aRR) = 1.19 (95% CI: 1.09, 1.30), in addition to symptoms of anxiety/depression during pregnancy, aRR = 1.17 (95% CI: 1.06, 1.29), and 6 months after delivery, aRR = 1.17 (95% CI: 1.07, 1.28). Maternal negative life events during pregnancy, aRR = 1.10 (95% CI: 1.06, 1.13), and 6 months after delivery, aRR = 1.14 (95% CI: 1.11, 1.18), were also associated with asthma. These associations were not replicated when evaluated within sibling groups. There were no associations with paternal psychosocial stress. In conclusion, maternal anxiety/depression and negative life events was associated with offspring asthma, but this might be explained by unmeasured maternal background characteristics that remain stable across deliveries.

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