Here are what the editors at HealthDay consider to be the most important developments in Cardiology for May 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Globally, Women Less Likely to Develop Heart Disease Than Men

FRIDAY, May 29, 2020 (HealthDay News) — Women are less likely to have or die from cardiovascular disease than men, according to a study published online May 20 in The Lancet.

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VA Slashes Use of Hydroxychloroquine to Treat COVID-19 Patients

FRIDAY, May 29, 2020 (HealthDay News) — The VA health system has stopped nearly all use of hydroxychloroquine to treat COVID-19 patients, Veterans Affairs Secretary Robert Wilkie said at a House hearing on Thursday.

AP News Article

Multiple Sclerosis Tied to Higher Risk for CVD, Cerebrovascular Disease

THURSDAY, May 28, 2020 (HealthDay News) — Multiple sclerosis (MS) is associated with an increased risk for cardiovascular and cerebrovascular disease that is not completely accounted for by traditional vascular risk factors, according to a study published online May 4 in JAMA Neurology.

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Tooth Loss More Prevalent in Adults With Chronic Disease

THURSDAY, May 28, 2020 (HealthDay News) — Adults with severe chronic disease or with fair or poor general health have a higher prevalence of edentulism and severe tooth loss, according to research published in the May 29 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Links Found Between Leaders of Medical Associations, Industry

THURSDAY, May 28, 2020 (HealthDay News) — There are extensive financial relationships between leaders of U.S. professional medical associations and industry, according to a study published online May 27 in The BMJ.

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CV Toxicity Tied to Azithromycin and/or Hydroxychloroquine

THURSDAY, May 28, 2020 (HealthDay News) — Hydroxychloroquine and azithromycin may have a serious adverse impact on the cardiovascular system, according to a research letter published online May 22 in Circulation.

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9.5 Percent Uninsured in U.S. From January Through June 2019

WEDNESDAY, May 27, 2020 (HealthDay News) — A total of 9.5 percent of persons were uninsured from January through June 2019, according to a report published online May 28 by the National Center for Health Statistics.

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Disease-Modifying Drug Regimen May Offer Benefit in Heart Failure

THURSDAY, May 28, 2020 (HealthDay News) — The treatment effects of early comprehensive disease-modifying pharmacological therapy are considerable for patients with heart failure with reduced ejection fraction (HFrEF), according to a study published online May 21 in The Lancet.

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Spirituality May Have Protective Effect on QOL for Stroke Survivors

THURSDAY, May 28, 2020 (HealthDay News) — High spirituality among stroke survivors may moderate the association between care partner depressive symptomatology and quality of life (QOL) for survivors and their care partners, according to a study published online May 26 in Circulation: Cardiovascular Quality and Outcomes.

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Outcomes Similar After TAVR in Bicuspid, Tricuspid Anatomy

WEDNESDAY, May 27, 2020 (HealthDay News) — All-cause mortality and stroke are comparable at 30 days and one year after transcatheter aortic valve replacement (TAVR) among patients with bicuspid and tricuspid valve stenosis, according to a study published online May 27 in JACC: Cardiovascular Interventions.

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Palliative Care Linked to Fewer Readmissions for Heart Failure

WEDNESDAY, May 27, 2020 (HealthDay News) — For patients admitted with heart failure, palliative care is associated with fewer readmissions and less mechanical ventilation, according to a study published online May 27 in the Journal of the American Heart Association.

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Only One in Four U.S. Hospitals With ICUs Have Tele-ICU Services

WEDNESDAY, May 27, 2020 (HealthDay News) — In 2018, half of U.S. hospitals had the capacity to conduct telehealth-based outpatient visits, while only one in four had tele-intensive care unit (tele-ICU) capabilities, according to a research letter published online April 30 in the Annals of Internal Medicine.

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WHO Suspends Testing of Hydroxychloroquine in COVID-19 Patients

TUESDAY, May 26, 2020 (HealthDay News) — The World Health Organization has suspended use of the antimalarial drug hydroxychloroquine in a clinical trial of treatments of COVID-19 after a study revealed that patients taking the drug are at increased risk for death and serious heart problems.

AP News Article

High Prevalence of Primary Aldosteronism Observed

TUESDAY, May 26, 2020 (HealthDay News) — Primary aldosteronism is prevalent and increases in parallel with hypertension severity, according to a study published online May 26 in the Annals of Internal Medicine.

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Right Ventricular Dilation Linked to Mortality in COVID-19

TUESDAY, May 26, 2020 (HealthDay News) — Right ventricular dilation is associated with in-hospital mortality among patients hospitalized with COVID-19, according to a study published online May 15 in JACC: Cardiovascular Imaging.

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Hydroxychloroquine Plus Macrolides No Benefit in COVID-19

TUESDAY, May 26, 2020 (HealthDay News) — For patients with COVID-19 requiring hospitalization, there is no evidence of benefit for use of hydroxychloroquine or chloroquine with or without a macrolide, according to a study published online May 22 in The Lancet.

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Cardiac Decompensation Seen in Children Following COVID-19

FRIDAY, May 22, 2020 (HealthDay News) — Children may experience acute cardiac decompensation due to a severe inflammatory state (multisystem inflammatory syndrome in children or MIS-C) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online May 17 in Circulation.

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Incidence of AMI Hospitalization Down During COVID-19

FRIDAY, May 22, 2020 (HealthDay News) — In Northern California, the incidence of hospitalization for acute myocardial infarction decreased during the COVID-19 pandemic period, according to a letter to the editor published online May 19 in the New England Journal of Medicine.

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Rate of Stroke Low in Hospitalized Patients With COVID-19

THURSDAY, May 21, 2020 (HealthDay News) — The rate of imaging-confirmed stroke is low in hospitalized patients with COVID-19, but mortality is higher than in contemporary controls without COVID-19 and historical controls, according to a study published online May 20 in Stroke.

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Factors Linked to COVID-19 In-Hospital Mortality ID’d in NYC

THURSDAY, May 21, 2020 (HealthDay News) — Factors associated with in-hospital mortality include older age, chronic cardiac disease, and chronic pulmonary disease in a cohort of hospitalized patients with COVID-19 in New York City, according to a study published online May 19 in The Lancet.

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Sex Differences ID’d in Prescription of Cardiovascular Meds

WEDNESDAY, May 20, 2020 (HealthDay News) — For patients at high risk for or with established cardiovascular disease in primary care, sex differences exist in the prescription of cardiovascular medications, according to a review published online May 20 in the Journal of the American Heart Association.

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Global Practice Guidelines Issued by International Society of Hypertension

WEDNESDAY, May 20, 2020 (HealthDay News) — In International Society of Hypertension practice guidelines, published in the June issues of Hypertension and the Journal of Hypertension, recommendations are presented for the management of hypertension in adults aged 18 years and older.

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Excessive Drinking Seen in Some Patients With Chronic Conditions

WEDNESDAY, May 20, 2020 (HealthDay News) — Among those reporting alcohol use, patients with certain common medical conditions are more likely to report excessive drinking, according to a study published online May 13 in JAMA Network Open.

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Higher Burden of Cardiovascular Risk Tied to Cognitive Decline

TUESDAY, May 19, 2020 (HealthDay News) — Higher cardiovascular risk burden is associated with cognitive decline and neurodegeneration, according to a study published in the May 26 issue of the Journal of the American College of Cardiology.

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Burnout Comparable Between Millennial, Gen X Residents, Fellows

TUESDAY, May 19, 2020 (HealthDay News) — Millennial and Generation X medical residents and fellows experience similar rates of burnout and have similar levels of empathy, according to a study published online May 5 in Academic Psychiatry.

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Spending on Primary Care Continues to Lag in the U.S.

TUESDAY, May 19, 2020 (HealthDay News) — Spending on inpatient services, specialty care, and prescriptions together accounted for about two-thirds of the increase in total U.S. health care spending from 2002 to 2016, according to a research letter published online May 18 in JAMA Internal Medicine.

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Higher Intake of Whole-Fat Dairy May Cut Metabolic Syndrome Risk

TUESDAY, May 19, 2020 (HealthDay News) — Higher intake of whole-fat dairy products is associated with a lower prevalence of metabolic syndrome (MetS) as well as hypertension and diabetes, according to a study published online May 18 in BMJ Open Diabetes Research & Care.

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28 Million-Plus Surgeries Could Be Canceled Due to COVID-19

TUESDAY, May 19, 2020 (HealthDay News) — Worldwide, more than 28 million elective surgeries could be canceled or postponed during the 12 weeks of peak disruption due to COVID-19, according to a study published online May 12 in the British Journal of Surgery.

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Osteoporotic Fracture Risk Lower for DOAC Than Warfarin in A-Fib

MONDAY, May 18, 2020 (HealthDay News) — For patients with atrial fibrillation (AF), the risk for osteoporotic fracture appears to be lower with direct oral anticoagulant (DOAC) use compared with warfarin use, according to a study published online May 19 in the Annals of Internal Medicine.

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Fruit-, Veggie-Rich Diet May Soon Lower Markers for Cardiac Injury

MONDAY, May 18, 2020 (HealthDay News) — For middle-aged adults without preexisting cardiovascular disease, eating a diet rich in fruits and vegetables over eight weeks is associated with lower levels of markers for subclinical cardiac damage and strain, according to a study published online May 19 in the Annals of Internal Medicine.

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Most Physicians Have Seen False-Negative COVID-19 Test Results

MONDAY, May 18, 2020 (HealthDay News) — Most physicians believe they have seen false-negative results for a COVID-19 diagnostic test, according to the results of a recent survey.

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Use of Imaging to Assess Stroke Down in Early COVID-19 Epoch

MONDAY, May 18, 2020 (HealthDay News) — From a prepandemic to early-pandemic epoch, there was a decrease in the use of imaging for the evaluation of stroke, according to a research letter published online May 8 in the New England Journal of Medicine.

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Hydroxychloroquine No Aid for COVID-19-Related Mortality

MONDAY, May 18, 2020 (HealthDay News) — Treating hospitalized COVID-19 patients with hydroxychloroquine, azithromycin, or both is not associated with improvements in in-hospital mortality, according to a study published online May 11 in the Journal of the American Medical Association.

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T2DM Linked to Worse Cognitive Performance After Stroke

FRIDAY, May 15, 2020 (HealthDay News) — In a stroke population, type 2 diabetes (T2D), but not impaired fasting glucose, is associated with worse cognitive performance, according to a study published online May 14 in Stroke.

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Intensive Blood Pressure Control Tied to Lower Atrial Fibrillation Risk

FRIDAY, May 15, 2020 (HealthDay News) — Intensive blood pressure (BP) control can lower the risk for atrial fibrillation (AF) in patients with hypertension at high risk for cardiovascular disease, according to a study published online May 4 in Hypertension.

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Kawasaki-Like Disease Incidence Up After Start of SARS-CoV-2

THURSDAY, May 14, 2020 (HealthDay News) — The incidence of Kawasaki-like disease increased after the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the Bergamo province of Italy, according to a study published online May 13 in The Lancet.

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COVID-19 Fatality Rate High for Heart Transplant Recipients

THURSDAY, May 14, 2020 (HealthDay News) — Heart transplant (HT) recipients with COVID-19 infection have a case fatality rate of 25 percent, according to a study published online May 13 in JAMA Cardiology.

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Guidance Issued for Acute Large Vessel CVA During COVID-19 Pandemic

THURSDAY, May 14, 2020 (HealthDay News) — In a guidance statement from the Society of Vascular and Interventional Neurology, published online April 29 in Stroke, recommendations are presented for the management of acute ischemic large vessel occlusion stroke during the COVID-19 pandemic.

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High Career Satisfaction Reported by Many Thoracic Surgeons

THURSDAY, May 14, 2020 (HealthDay News) — Thoracic surgeons have high career satisfaction, but more than half report symptoms of burnout and depression, according to a study published online May 14 in the Annals of Thoracic Surgery.

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Deceased Donor Transplantation Has Dropped Since COVID-19

WEDNESDAY, May 13, 2020 (HealthDay News) — Since the COVID-19 outbreak, there has been a reduction in deceased donor transplantations in France and the United States, according to a research letter published online May 11 in The Lancet.

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Sugar-Sweetened Beverages May Increase Risk for CVD in Women

WEDNESDAY, May 13, 2020 (HealthDay News) — Sugar-sweetened beverage (SSB) consumption is associated with an increased risk for cardiovascular disease (CVD), revascularization, and stroke among women, according to a study published online May 13 in the Journal of the American Heart Association.

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Gap in Rural, Urban CVD Deaths Grew From 1999 to 2017

TUESDAY, May 12, 2020 (HealthDay News) — The gap between rural and urban areas grew for cardiovascular disease age-adjusted mortality rates (AAMRs) between 1999 and 2017, according to a research letter published in the May 12 issue of the Journal of the American Medical Association.

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USPSTF Urges Behavioral Counseling for Those With CVD Risk

TUESDAY, May 12, 2020 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends behavioral counseling to promote a healthy lifestyle for adults at risk for cardiovascular disease. These recommendations form the basis of a draft recommendation statement published online May 12 by the USPSTF.

Draft Evidence Review
Draft Recommendation Statement
Comment on Recommendation Statement

Dexrazoxane Preserves Cardiac Function in Pediatric Leukemia

TUESDAY, May 12, 2020 (HealthDay News) — For pediatric patients with acute myeloid leukemia (AML), dexrazoxane preserves cardiac function without affecting survival, according to a study published online April 28 in the Journal of Clinical Oncology.

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Thigh Circumference Tied to Hypertension Risk

TUESDAY, May 12, 2020 (HealthDay News) — Large thigh circumference is associated with a lower risk for hypertension in overweight and obese individuals, according to a study published in the April issue of Endocrine Connections.

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Severe Illness Reported in Some Children With COVID-19

TUESDAY, May 12, 2020 (HealthDay News) — Severe illness from COVID-19 infection occurs in some children, most of whom have significant preexisting comorbidities, according to a study published online May 11 in JAMA Pediatrics.

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For Those With Heart Failure, ACE2 Concentrations Up in Men

TUESDAY, May 12, 2020 (HealthDay News) — Among patients with heart failure, men have higher plasma concentrations of angiotensin-converting enzyme 2 (ACE2), while neither use of angiotensin-converting enzyme (ACE) inhibitors nor angiotensin receptor blockers (ARBs) are associated with increased plasma ACE2 concentrations, according to a study published online May 10 in the European Heart Journal.

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Residual Shunt After PFO Closure Linked to Higher Risk for Stroke

MONDAY, May 11, 2020 (HealthDay News) — The presence of a residual shunt after patent foramen ovale (PFO) closure is associated with an increased risk for recurrent stroke or transient ischemic attack (TIA), according to a study published online May 12 in the Annals of Internal Medicine.

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Cardiorespiratory Fitness Aids Mortality Prediction

MONDAY, May 11, 2020 (HealthDay News) — Cardiorespiratory fitness (CRF) improves mortality risk prediction beyond conventional risk factors, according to a study published in the May issue of Mayo Clinic Proceedings.

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Incidence of Psych Morbidity Up With Spinal Cord Injury

FRIDAY, May 8, 2020 (HealthDay News) — Adults with traumatic spinal cord injuries (SCIs) have an increased incidence of psychological morbidities and multimorbidity, according to a study published in the May issue of Mayo Clinic Proceedings.

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ACE Inhibitor/ARB Use Not Tied to COVID-19 Test Positivity

FRIDAY, May 8, 2020 (HealthDay News) — Angiotensin-converting enzyme inhibitor (ACEI) and/or angiotensin receptor blocker (ARB) use is not associated with COVID-19 test positivity, according to a study published online May 5 in JAMA Cardiology.

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CDC: Prevalence of Hypertension Higher in Rural Versus Urban Areas

FRIDAY, May 8, 2020 (HealthDay News) — The prevalence of hypertension varies across states and is higher in rural versus urban areas, according to research published in the May 8 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Death and Disability From Stroke Down in United Kingdom

FRIDAY, May 8, 2020 (HealthDay News) — The risk for death and disability after a stroke fell significantly between 2000 and 2015 in the United Kingdom, according to a study recently published in PLOS Medicine.

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Endovascular Thrombectomy Alone Noninferior in Ischemic Stroke

THURSDAY, May 7, 2020 (HealthDay News) — Endovascular thrombectomy alone is noninferior to endovascular thrombectomy preceded by intravenous alteplase for patients with acute ischemic stroke from large-vessel occlusion, according to a study published online May 6 in the New England Journal of Medicine.

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New York State Reports Cases of Pediatric Inflammatory Syndrome Tied to COVID-19

THURSDAY, May 7, 2020 (HealthDay News) — The New York State Department of Health issued an advisory on May 6 regarding cases of pediatric multisystem inflammatory syndrome potentially associated with COVID-19.

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Link Found Between Body Size in Childhood, Later Life Disease

THURSDAY, May 7, 2020 (HealthDay News) — Large adult body size contributes to the association between genetically predicted larger body size in childhood and coronary artery disease and type 2 diabetes later in life, according to a study published online May 6 in The BMJ.

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Cardio-Obstetrics Team Key to Managing CVD in Pregnancy

THURSDAY, May 7, 2020 (HealthDay News) — A cardio-obstetrics team is essential for management of cardiovascular disease during pregnancy, according to an American Heart Association scientific statement published online May 4 in Circulation.

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Teen Obesity, T2DM, HTN May Lead to Early Vascular Aging

WEDNESDAY, May 6, 2020 (HealthDay News) — The presence of obesity, type 2 diabetes, and elevated systolic blood pressure (SBP) in adolescence accelerates the progression of risk factors that play a role in the development of early vascular aging, according to a study published online May 6 in the Journal of the American Heart Association.

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ACE Inhibitors, ARBs Not Linked to In-Hospital COVID-19 Death

WEDNESDAY, May 6, 2020 (HealthDay News) — Age and underlying cardiovascular disease are associated with in-hospital mortality in COVID-19, according to a study published online May 1 in the New England Journal of Medicine.

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Race and Income Influence Risk for Severe COVID-19

TUESDAY, May 5, 2020 (HealthDay News) — Race and income influence the risk for severe illness from COVID-19, according to a study published online April 28 in the American Journal of Preventive Medicine.

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Incidence of HTN Disorders of Pregnancy Underestimated

TUESDAY, May 5, 2020 (HealthDay News) — The incidence of hypertensive disorders of pregnancy (HDP) is underestimated when assessed on a per-pregnancy basis and confers a significant increase in risks for cardiovascular and kidney diseases, according to a study published in the May 12 issue of the Journal of the American College of Cardiology.

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Out-of-Hospital Cardiac Arrests Increased in Italy in 2020

TUESDAY, May 5, 2020 (HealthDay News) — The incidence of out-of-hospital cardiac arrest was strongly associated with the cumulative incidence of COVID-19 in 2020 in Lombardy, Italy, according to a research letter published online April 29 in the New England Journal of Medicine.

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More Rural Stroke Patients Now Treated at Certified Stroke Centers

TUESDAY, May 5, 2020 (HealthDay News) — In the last decade, there has been a shift toward care in certified stroke centers for rural residents with acute ischemic stroke and transient ischemic attack, according to a study published online May 4 in JAMA Neurology.

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ACE Inhibitors, ARBs Not Linked to Risk for COVID-19

TUESDAY, May 5, 2020 (HealthDay News) — Use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) and other classes of antihypertensive medications seem not to be associated with COVID-19, according to two studies published online May 1 in the New England Journal of Medicine.

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High Alcohol Consumption May Be Causally Tied to Stroke, PAD

TUESDAY, May 5, 2020 (HealthDay News) — Higher alcohol consumption may be causally associated with an increased risk for stroke and peripheral artery disease, according to a study published online May 5 in Circulation: Genomic and Precision Medicine.

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Evolocumab Does Not Impact Cognition in Atherosclerotic CVD

MONDAY, May 4, 2020 (HealthDay News) — For patients with atherosclerotic cardiovascular disease and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL or non-high-density cholesterol ≥100 mg/dL despite statin therapy, evolocumab has no impact on patient-reported cognitive function, according to a study published in the May 12 issue of the Journal of the American College of Cardiology.

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Sleep Apnea Tied to High Blood Glucose Levels Among Blacks

MONDAY, May 4, 2020 (HealthDay News) — Black Americans with severe sleep apnea are more likely to have high blood glucose levels, according to a study published online April 28 in the Journal of the American Heart Association.

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Hydroxychloroquine in COVID-19 Ups Risk for QTc Prolongation

MONDAY, May 4, 2020 (HealthDay News) — Patients with COVID-19 who receive hydroxychloroquine have a high risk for corrected QT (QTc) prolongation, according to a study published online May 1 in JAMA Cardiology.

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ATS Issues Guideline on the Diagnosis of Sarcoidosis

MONDAY, May 4, 2020 (HealthDay News) — In an official American Thoracic Society clinical practice guideline, published online April 15 in the American Journal of Respiratory and Critical Care Medicine, recommendations are presented for the detection and diagnosis of sarcoidosis.

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CV Outcomes Improved in Those With, Without Type 2 Diabetes

FRIDAY, May 1, 2020 (HealthDay News) — Cardiovascular outcomes have improved since the 1990s, especially for individuals with type 2 diabetes, according to a study published online April 30 in the Journal of Clinical Endocrinology & Metabolism.

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Vascular Stiffness Similar in E-, Combustible Cigarette Users

FRIDAY, May 1, 2020 (HealthDay News) — Electronic cigarette (e-cigarette) use with or without combustible cigarette use is associated with a similar elevation in the augmentation index compared with combustible cigarette use alone, according to a study published online April 29 in the Journal of the American Heart Association.

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RV Strain on Echocardiogram May ID High-Risk COVID-19 Patients

FRIDAY, May 1, 2020 (HealthDay News) — Right ventricular longitudinal strain (RVLS) is a predictor of mortality in patients with COVID-19, according to a study published online April 28 in JACC: Cardiovascular Imaging.

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