To assess the interchangeability of the Health Assessment Questionnaire‐Disability Index (HAQ‐DI) with the Patient‐Reported Outcomes Measurement Information System‐Physical Function (PROMIS‐PF) in the calculation of minimal disease activity (MDA) in psoriatic arthritis (PsA).
Comprehensive PsA disease activity was collected concomitantly with HAQ‐DI and PROMIS‐PF measures in a PsA cohort. PROMIS‐based MDA definitions were built using the existing cross‐walk between the scores: HAQ‐DI≤0.5 equivalent to a PROMIS‐PF T-score≥41.3. We assessed agreement between MDA (MDA HAQ‐DI) and PROMIS‐PF MDA definitions (MDA PROMIS‐PF4a, MDA PROMIS‐PF Bank) at each visit and longitudinally (MDA state changes between consecutive visits) through the kappa statistic. The predictive value of MDA PROMIS‐PF for MDA HAQ‐DI was assessed using ROC curve analysis.
One hundred participants contributed 352 observations with up to five visits. Mean (SD) age was 52 (12) years, 60% were female, and 43% were in MDA at baseline. Kappa statistic for PROMIS‐PF based MDA reflected excellent agreement with HAQ‐DI MDA: kappa=0.94 (95% CI 0.90‐0.97) for MDA PROMIS‐PF Bank, and kappa=0.90 (95% CI 0.80‐0.95) for MDAPROMIS‐PF4a. The higher longitudinal agreement was seen between MDA HAQ‐DI and MDA PROMIS‐PF Bank versus MDA PROMIS‐PF4a between consecutive visits: kappa ranged between 0.81‐0.94 versus 0.72‐0.84, respectively. The area under the ROC curve for predicting MDA HAQ‐DI was 0.97 for MDA PROMIS‐PF Bank and 0.95 for MDA PROMIS‐PF4a.
Excellent agreement was seen between HAQ‐DI and PROMIS‐based MDA definitions statically and longitudinally. The PROMIS‐PF Bank and PROMIS‐PF4a are accurate replacements for the HAQ‐DI in calculating the MDA state in PsA.
Ref: https://onlinelibrary.wiley.com/doi/10.1002/acr.24433
