This position paper outlines current knowledge of the medical therapy of chronic pancreatitis (CP) in children based on available medical literature, including recent improvements in understanding of nutrition, pain, lifestyle factors, and CP sequelae. This article supplements and integrates related position papers on endoscopic and surgical aspects of CP in children. Concepts and debates around pancreatic enzyme replacement therapy (PERT), the use of antioxidants, and other CP medical treatments are also discussed.

Among the highlights are tools for medical decision-making for PERT, CP-related diabetes, and multimodal pain treatment (including an analgesia ladder). Gaps in our understanding of CP in children are also discussed, as are future research directions.