Health state utility values (HSUVs) are vital in health economic modeling, but HSUVs of people with osteoarthritis (OA)‐related conditions have not been systematically reviewed and meta-analyzed. This study aimed to examine and meta-analyze the HSUVs for people with OA systematically. HSUVs for people with knee, hip, and mixed OA in pre-and post‐treatment populations were meta-analyzed using random-effects models.

One‐hundred and fifty‐one studies were included in the systematic review, and 88 in meta‐analyses. Of 151 studies, 56% were conducted in Europe, 75% were in people with knee, and hip OA and 79% were based on the EQ‐5D. The pooled mean (95% confidence interval [CI]) baseline HSUVs for knee OA core interventions, medication, injection and primary surgery treatments were 0.64 (0.61–0.66), 0.56 (0.45−0.68), 0.58 (0.50–0.66) and 0.52 (0.49–0.55), respectively. These were 0.71 (0.59–0.84) for hip OA core interventions and 0.52 (0.49–0.56) for hip OA primary surgery. For all knee OA treatments and hip OA primary surgery, pooled HSUVs were significantly higher in the post‐ than the pre-treatment populations.

In conclusion, this study provides a comprehensive summary of OA‐related HSUVs. It generates an HSUVs database for people with different affected OA joint sites undergoing other treatments to guide HSUV choices in future health economic modeling of OA interventions.