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Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study.

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study.
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Zeng H, Tong R, Tong W, Yang Q, Qiu M, Xiong A, Sun S, Ding L, Zhang H, Yang L, Tian J,


Zeng H, Tong R, Tong W, Yang Q, Qiu M, Xiong A, Sun S, Ding L, Zhang H, Yang L, Tian J, (click to view)

Zeng H, Tong R, Tong W, Yang Q, Qiu M, Xiong A, Sun S, Ding L, Zhang H, Yang L, Tian J,

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Scientific reports 2017 07 267(1) 6575 doi 10.1038/s41598-017-06309-6
Abstract

To investigate the metabolic biomarkers of predicting the transition from pre-diabetes (pre-DM) to normal glucose regulation (NGR) and diabetes (DM) in a longitudinal cohort study. 108 participants with pre-DM were followed up for ten years and divided into 3 groups according to different glycemic outcomes. 20 participants progressed to DM, 20 regressed to NGR, and 68 remained at pre-DM. Alterations in plasma metabolites in these groups were evaluated by untargeted ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Twenty three metabolites related to glycerophospholipid metabolism, oxidation and antioxidation were associated with the process from pre-DM to NGR, while twenty two metabolites related to amino acid metabolism, glycerophospholipid metabolism and mitochondrial β-oxidation played important roles in the progression to DM. Results from stepwise logistic regression analysis showed that five biomarkers (20-Hydroxy-leukotriene E4, Lysopc(20:4), 5-methoxytryptamine, Endomorphin-1, Lysopc(20:3)) were good prediction for the restoration to NGR, and five biomarkers (Iso-valeraldehyde, linoleic acid, Lysopc(18:1), 2-Pyrroloylglycine, Dityrosine) for the development of DM. The findings suggest that the combination of these potential metabolites may be used for the prognosis of pre-DM. Targeting the pathways that involved in these prognostic biomarkers would be beneficial for the regression to NGR and the early prevention of DM among pre-DM.

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