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MicroRNA mediated regulation of immunity against gram-negative bacteria.

MicroRNA mediated regulation of immunity against gram-negative bacteria.
Author Information (click to view)

Keck J, Gupta R, Christenson LK, Arulanandam BP,


Keck J, Gupta R, Christenson LK, Arulanandam BP, (click to view)

Keck J, Gupta R, Christenson LK, Arulanandam BP,

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International reviews of immunology 2017 08 11() 1-13 doi 10.1080/08830185.2017.1347649

Abstract

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

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