Mifepristone, followed 48 hours later by administration of misoprostol, is a well-established regimen for medical termination of pregnancy (TOP). Although this regimen is effective, its inflexibility may limit its provision in outpatient service.

Researchers conducted this study to confirm that misoprostol administration is effective whether administered 24, 48, or 72 hours after oral mifepristone.

The study design used was an observational study of 234 consecutive women with pregnancies up to 83 days’ gestational age in whom medical TOP was performed during the period December 2000-July 2001.

The study setting was the Women’s Health Care Department, Royal Bolton Hospital, Bolton, UK.

There was a high success rate for complete abortion in all groups whether mifepristone was administered 24, 48, or 72 hours before misoprostol.

This study concluded that a more flexible regimen of mifepristone/misoprostol administration for medical TOP is useful in routine clinical practice. Medical termination is ordinary; therefore, it is important to under the impacts of some medications. The patient’s behavior needs to be assessed to see if they will take proper care or not. Effect of drugs is an area of interest to provide the best services to patients.

Reference: https://srh.bmj.com/content/29/3/139