Advertisement

 

 

MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia.

MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia.
Author Information (click to view)

Ma QL, Wang JH, Yang M, Wang HP, Jin J,


Ma QL, Wang JH, Yang M, Wang HP, Jin J, (click to view)

Ma QL, Wang JH, Yang M, Wang HP, Jin J,

Advertisement

Journal of translational medicine 2018 03 1416(1) 68 doi 10.1186/s12967-018-1445-3

Abstract
BACKGROUND
MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of this study was to determine whether the expression of miR-362-5p can be served as a prognostic factor for patients with cytogentically normal acute myeloid leukemia (CN-AML).

METHODS
We enrolled 224 patients with CN-AML and measured the expression of miR-362-5p by quantitative real time PCR analysis. We classified patients into high and low expression based on the median value. The Cox regression analyses were carried out to assess the prognostic significance of miR-362-5p expression in the context of the well-established predictors. Additionally, microRNA expression profiling were conducted to identify the biological insights between high and low group.

RESULTS
High expressers had older age. High expressers obtained shorter overall survival in the univariate analysis. The independent prognostic value of miR-362-5p remained in the context of the well-established clinical and cytogenetic predictors. Moreover, the prognostic value of miR-362-5p was also validated in an independent cohort of CN-AML. Notably, numerous oncomiRs were also high expressed in high miR-362-5p group.

CONCLUSION
High miR-362-5p expression was associated with poorer overall survival implicating the oncogenic function in AML development.

Submit a Comment

Your email address will not be published. Required fields are marked *

fourteen + 10 =

[ HIDE/SHOW ]