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MiRNA-binding site variants of type 2 diabetes candidate loci predispose to gestational diabetes mellitus in Chinese Han women.

MiRNA-binding site variants of type 2 diabetes candidate loci predispose to gestational diabetes mellitus in Chinese Han women.
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Wang X, Li W, Ma L, Ping F, Liu J, Wu X, Mao J, Wang X, Nie M,


Wang X, Li W, Ma L, Ping F, Liu J, Wu X, Mao J, Wang X, Nie M, (click to view)

Wang X, Li W, Ma L, Ping F, Liu J, Wu X, Mao J, Wang X, Nie M,

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Journal of diabetes investigation 2018 01 20() doi 10.1111/jdi.12803
Abstract
AIMS/INTRODUCTION
Emerging evidence suggested that the genetic background of GDM was analogous to T2DM. In contrast to T2DM, the genetic studies for GDM were limited. Accordingly, the aim of this study was to extensively explore the influence of miR-binding-SNPs in T2DM candidate loci on GDM susceptibility in Chinese.

METERIALS AND METHODS
A total of 839 GDM and 900 controls were enrolled. Six miR-binding-SNPs were selected from 30 T2DM susceptibility loci and genotyped using TaqMan allelic discrimination assays.

RESULTS
The minor allele of three SNPs, PAX4 rs712699 [OR 95% CI=1.366(1.021, 1.828), P = 0.036], KCNB1 rs1051295 [OR 95% CI = 1.579(1.172, 2.128), P = 0.003] and MFN2 rs1042842 [OR 95% CI =1.398 (1.050, 1.862), P = 0.022] were identified to significantly confer higher risk of GDM in additive model. The association between rs1051295 and increased fasting plasma glucose (b=0.006, P= 0.008), 3h-OGTT plasma glucose (b=0.058, P=0.025) and HOMA-IR (b=0.065, p=0.017) was also demonstrated. Rs1042842 was correlated with higher 3h-OGTT plasma glucose (b=0.056, P=0.028). However, no significant correlation between the other included SNPs (LPIN1 rs1050800, VPS26A rs1802295 and NLRP3 rs10802502) and GDM susceptibility were observed.

CONCLUSIONS
Our findings indicated that miR-binding-SNPs in T2DM candidate loci were also associated with GDM susceptibility, which further highlighted the similar genetic basis underlying GDM and T2DM. This article is protected by copyright. All rights reserved.

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