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Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.

May 05, 2025

REFERENCES & ADDITIONAL READING

PubMed

ABOUT THE EXPERTS

  • Melanie Paillard

    Laboratoire CarMeN-IRIS Team, INSERM, INRA, Université Claude Bernard Lyon-1, Bron, France.

    Mahmoud Abdellatif

    Division of Cardiology, Department of Internal Medicine, Medical University of Graz, BioTechMed Graz, Graz, Austria.

    Ioanna Andreadou

    Laboratory of Pharmacology, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

    Christian Bär

    Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany-Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.

    Luc Bertrand

    UCLouvain, Institute for Experimental and Clinical Research, Pole of Cardiovascular Research; WELBIO Department, WEL Research Institute, Brussels, Belgium.

    Bianca J J M Brundel

    Physiology, Amsterdam UMC Location Vrije Universiteit, Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam, The Netherlands.

    Gemma Chiva-Blanch

    Faculty of Health Sciences, Universitat Oberta de Catalunya, Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Clínic of Barcelona, Barcelona, Spain.

    Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

    Sean M Davidson

    The Hatter Cardiovascular Institute, University College London, London, UK.

    Dana Dawson

    Aberdeen Cardiovascular and Diabetes Centre, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK.

    Fabio Di Lisa

    Department of Biomedical Sciences, University of Padua, Padova, Italy.

    Paul Evans

    William Harvey Research Institute, Queen Mary University of London, London, UK.

    Zoltan Giricz

    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.

    Derek J Hausenloy

    The Hatter Cardiovascular Institute, University College London, London, UK.

    National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.

    Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.

    Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore.

    Petra Kleinbongard

    Institute of Pathophysiology, Faculty of Medicine University of Duisburg-Essen, Duisburg, Germany.

    Frank Lezoualc’h

    Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, University of Toulouse III – Paul Sabatier, Toulouse, France.

    Elisa Liehn

    Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark.

    Department of Translational Research, Comprehensive Heart Failure Center (CHFC), and Medical Clinic I, University Clinic Würzburg, Würzburg, Germany.

    Christoph Maack

    Department of Translational Research, Comprehensive Heart Failure Center (CHFC), and Medical Clinic I, University Clinic Würzburg, Würzburg, Germany.

    Ange Maguy

    Atrial Fibrillation and Therapeutic Innovation, Department of Physiology, Faculty of Medicine, University of Bern, Bern, Switzerland.

    Elizabeth Murphy

    Cardiac Physiology, NHLBI, NIH, Bethesda, MD, USA.

    Cinzia Perrino

    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.

    Maurizio Pesce

    Unit of Cardiovascular Tissue Engineering, Centro Cardiologico Monzino, IRCCS, Milan, Italy.

    Department of Cell Biology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

    Department of Mechanical and Aerospace Engineering (DIMEAS), Turin School of Engineering, Turin, Italy.

    Peter P Rainer

    Division of Cardiology, Department of Internal Medicine, Medical University of Graz, BioTechMed Graz, Graz, Austria.

    Katrin Streckfuss-Bömeke

    Institute of Pharmacology and Toxicology, University of Würzburg, Germany-Clinic for Cardiology and Pneumology, University Medicine Göttingen, and German Center for Cardiovascular Research (DZHK), Partner site Göttingen, Göttingen, Germany.

    Matthias Thielmann

    West-German Heart & Vascular Center, University Duisburg-Essen, Essen, Germany.

    Rong Tian

    Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA, USA.

    Carlo G Tocchetti

    Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research, Interdepartmental Center of Clinical and Translational Sciences, Interdepartmental Hypertension Research Center, Federico II University, Naples, Italy.

    Jolanda Van Der Velden

    Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, The Netherlands-Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam, The Netherlands.

    Sophie Van Linthout

    Berlin Institute of Health (BIH) at Charité, Universitätmedizin Berlin, Germany, BIH Center for Regenerative Therapies (BCRT), German Center for Cardiovascular Research (DZHK), Partner site Berlin, Berlin, Germany.

    Serena Zacchigna

    Laboratory of Cardiovascular Biology, The International Centre for Genetic Engineering and Biotechnology, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

    Thomas Krieg

    Department of Medicine, University of Cambridge, Cambridge, UK.

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