A novel prognostic model demonstrated efficacy for predicting worse disease-free survival (DFS) following liver resection in patients with proliferative hepatocellular carcinoma (HCC), according to results published in the Journal of Hepatocellular Carcinoma. Researchers assessed patients with solitary HCC who underwent curative liver resection (N=816), assigning them to the proliferative HCC cohort (n=259) or the non proliferative HCC cohort (n=557) based on histologic criteria. The study team compared DFS between the groups before and after one-to-one propensity score matching (PSM). DFS for proliferative HCC was significantly worse than non proliferative HCC before and after PSM. Multivariate regression analysis showed that liver cirrhosis (P=0.032) and larger tumor size (P<0.001) were independent risk factors for worse DFS. The discriminative abilities of the predictive model for 1, 3, and 5-year DFS rates, as determined by receiver operating characteristic curves, were 0.702, 0.720, and 0.809 in the training cohort and 0.752, 0.776, and 0.851 in the validation cohort, respectively.
