Greater skin clearance among patients with psoriasis is associated with greater improvements in quality of life, according to a letter to the editor published in the Journal of the American Academy of Dermatology. Investigators evaluated the association of body surface area (BSA) with quality of life (assessed by the Dermatology Life Quality Index [DLQI]) after 6 and 12 months of treatment with systemic therapy. The analysis included 665 patients identified through the Corrona Psoriasis Registry (April 2015 to May 2017). The relative change in DLQI improved as BSA improved. Patients who achieved a BSA of 0% had a 57% improvement in the DLQI score at 6 months. At 12 months, patients in the BSA greater than 3% group at the 12-month visit had worsening of the DLQI by 46%, while the 15% of patients who achieved BSA of 0% had a 71% improvement in the DLQI score. The association between BSA achievement and relative improvements in the DLQI was significant at 6 and 12 months. “The results of our study further strengthen the evidence supporting the utility of BSA as an indicator of improvement in patient quality of life,” the authors write.
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