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Mortality and Comorbidity Profiles of Patients with Bullous Pemphigoid in Korea.

Mortality and Comorbidity Profiles of Patients with Bullous Pemphigoid in Korea.
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Jeon HW, Yun SJ, Lee SC, Won YH, Lee JB,


Jeon HW, Yun SJ, Lee SC, Won YH, Lee JB, (click to view)

Jeon HW, Yun SJ, Lee SC, Won YH, Lee JB,

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Annals of dermatology 2017 12 2630(1) 13-19 doi 10.5021/ad.2018.30.1.13
Abstract
Background
Bullous pemphigoid (BP) is a common autoimmune-mediated blistering skin disease that is significantly associated with mortality and morbidity. However, few studies regarding the mortality and comorbidity profiles of BP have been reported in Korea.

Objective
To evaluate and compare the mortality, comorbidity profiles, and risk factors between patients with BP who visited our clinic and an age-matched general population of Korea.

Methods
We retrospectively evaluated 103 patients diagnosed with BP between 2006 and 2013 at Chonnam National University Hospital in Gwangju, Korea.

Results
The 1-year, 2-year, and 5-year mortality rates of the patients were 18.44%, 28.16%, and 42.00%, respectively. The median age was 76 years (range, 41~96 years). The standardized mortality ratio of patients with BP was 1.83 times that of the age- and sex-matched general population of Korea. Old age at the time of diagnosis, cardiac disease and renal disease were associated with increased 5-year mortality. In addition, the prevalence of diabetes, stroke, dementia, and Parkinson’s disease was higher among BP patients than in the general population.

Conclusion
The mortality rate of patients with BP is higher than that of the general Korean population. Korean patients with BP are more likely to have dementia, Parkinson’s disease, diabetes, and stroke. Risk factors for increased 5-year mortality include old age at the time of diagnosis and medical comorbidities, especially cardiac disease and renal disease.

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