There have been many studies conducted so far in order to measure the amount of human monoclonal antibody that is in the position to inhibit granulocyte and macrophage the colony-stimulating factor. Therefore, an attempt is made to understand the ratio of inflammation which might follow to evaluate the effect of otilimab on the GM-CSF-chemokine ligand axis and synovitis in patients with rheumatoid arthritis. Therefore, in phase 2 trials a population of 487 patients was analyzed and all the people in that ratio were above the age of 18 years. It was observed in the results that nearly in the ratio of 3:1, people had an interactive response to the technology which seemed to more effective than the process of MRI and hence, it was capable of providing with the best of the primary, secondary and tertiary biomarkers in the proportion of 87 percent so far. The results concluded that the serum concentrations in the ratio of 4:5 were in the position to induce the complex structure of the target enhancement that was achieved with the initial loss and at the same time was not linked with the targeted dosing. CCL17might be in the position to a pharmacodynamic biomarker for the purposes of otilimab and hence, the results of 12 weeks were showing the same outcome and effor

Ref art: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30224-1/fulltext