There is limited information on the characteristics, prognostic factors, and outcomes of patients with MM hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals to understand the characteristics, prognostic factors, and outcomes of patients with MM hospitalized with COVID-19.
Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 as the controls who were admitted at six participating hospitals. COVID-19 clinical severity was moderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. The findings of this study demonstrate that the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19.