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Multiple Myeloma Presenting with Autoimmune Autonomic Ganglionopathy.

Multiple Myeloma Presenting with Autoimmune Autonomic Ganglionopathy.
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Nakae Y, Hyuga M, Kishimoto W, Fukunaga A, Tabata S, Maesako Y, Arima N, Terada Y, Komatsu K, Higuchi O, Nakane S,


Nakae Y, Hyuga M, Kishimoto W, Fukunaga A, Tabata S, Maesako Y, Arima N, Terada Y, Komatsu K, Higuchi O, Nakane S, (click to view)

Nakae Y, Hyuga M, Kishimoto W, Fukunaga A, Tabata S, Maesako Y, Arima N, Terada Y, Komatsu K, Higuchi O, Nakane S,

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Internal medicine (Tokyo, Japan) 2017 10 11() doi 10.2169/internalmedicine.9096-17
Abstract

Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma. Treatment for multiple myeloma may improve autoimmune autonomic ganglionopathy.

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