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Multiple Tests Identified to Better Predict Heart Disease Risk

Multiple Tests Identified to Better Predict Heart Disease Risk
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UT Southwestern Medical Center


UT Southwestern Medical Center (click to view)

UT Southwestern Medical Center

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Five simple medical tests together provide a broader and more accurate assessment of heart-disease risk than currently used methods, cardiologists at UT Southwestern Medical Center found.

Combined, results from the five tests – an EKG, a limited CT scan, and three blood tests – better predict who will develop heart disease compared with standard strategies that focus on blood pressure, cholesterol, diabetes, and smoking history, researchers reported.

“This set of tests is really powerful in identifying unexpected risk among individuals with few traditional risk factors. These are people who would not be aware that they are at risk for heart disease and might not be targeted for preventive therapies,” said Dr. James de Lemos, Professor of Internal Medicine.

The five tests, and the information they provide:

  • A 12-lead EKG provides information about hypertrophy, or thickening of the heart muscle.
  • A coronary calcium scan, a low-radiation imaging test, identifies calcified plaque buildup in the arteries of the heart.
  • A blood test for C-reactive protein indicates inflammation.
  • A blood test for the hormone NT-proBNP indicates stress on the heart.
  • A blood test for high-sensitivity troponin T indicates damage to heart muscle. Troponin testing is regularly used by hospitals to diagnose heart attacks, but high-sensitivity troponin fine-tunes that measure, pointing to small amounts of damage that can be detected in individuals without any symptoms or warning signs.

Four of the five tests are currently readily available and the fifth – high-sensitivity troponin T – will be available soon.


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