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Redefining MI After Revascularization

Redefining MI After Revascularization
Author Information (click to view)

Issam D. Moussa, MD, FSCAI

Chair, Division of Cardiovascular Disease
Mayo Clinic Florida
Professor of Medicine
Mayo Clinic College of Medicine

Issam D. Moussa, MD, FSCAI, has indicated to Physician’s Weekly that he has no financial disclosures to report.

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Issam D. Moussa, MD, FSCAI (click to view)

Issam D. Moussa, MD, FSCAI

Chair, Division of Cardiovascular Disease
Mayo Clinic Florida
Professor of Medicine
Mayo Clinic College of Medicine

Issam D. Moussa, MD, FSCAI, has indicated to Physician’s Weekly that he has no financial disclosures to report.

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A standardized MI definition can help clinicians better identify patients with true complications after PCI or CABG who require urgent action.

Numerous definitions for diagnosing myocardial infarction (MI) after coronary revasculariza­tion are currently being used by clinicians. In 2013, the Society for Cardiovascular Angiography and Interven­tions (SCAI) convened an expert panel that proposed new, more meaningful cri­teria for diagnosing MI after PCI or CABG. “Having a standardized MI definition can help clinicians better identify patients with true complications after PCI or CABG who require urgent action,” says Issam D. Moussa, MD, FSCAI, lead author of the SCAI consensus document. “It would also better reflect the quality of coronary revascularization procedures and assist in the design of research trials aimed at developing effective prevention strategies.”

New Criteria

The new definition of MI differs from existing definitions in several ways, according to Dr. Moussa. “Both diagnose MI by detecting proteins in the blood that are released when the heart muscle is damaged,” he says. “The universal definition calls for a relatively small increase in cardiac troponin (up to five times the normal level), plus confirmation by an ECG, an imaging test, or symptoms. On the other hand, the new SCAI definition calls for a large increase in CK-MB (up to at least 10 times the normal level) in most cases.” If CK-MB is unavailable, SCAI’s new definition calls for a troponin level that is 70 times the normal level. If an ECG provides strong evidence of an MI, then the new definition allows for blood levels of CK-MB that are five times normal and troponin that is 35 times normal.

Redefine-MI-Callout

“When patients are diagnosed with an MI, there are important implications to consider,” Dr. Moussa. “These diagnoses could lead to longer hospitalizations, more blood tests, and repeat imaging procedures. How we define MI after PCI or CABG can have a significant impact on how patients are managed.”

Potential Advantages

The new definition from SCAI offers additional advantages over previous definitions, according to Dr. Moussa. “The new criteria focus on the link between a large rise in CK-MB levels and poor long-term outcomes after PCI or CABG. Troponin is the preferred protein marker to use when diagnosing spontaneous MI, but its role in diagnosing prognostically important MIs after coronary revascularization has not been well validated. This new criteria can also bring uniformity to how MIs are diagnosed after both PCI and CABG. At the same time, it should be noted that these criteria are based on the best scientific evidence that is currently available. More research is needed to better understand the issues surrounding the diagnosis and prognosis of these events, and it’s likely this definition will be revised as new data become available.”

Readings & Resources (click to view)

Moussa ID, Klein LW, Shah B, et al. Consideration of a new definition of clinically relevant myocardial infarction after coronary revascularization: an expert consensus document from the Society for Cardiovascular Angiography and Interventions (SCAI). Catheter Cardiovasc Interv. 2013 Oct 16 [Epub ahead of print]. Available at: http://onlinelibrary.wiley.com/doi/10.1002/ccd.25135/pdf. For more information, go to: http://www.scai.org/Press/detail.aspx?cid=c3a3efc0-15d4-4ec4-b807-a803a1ce7238.

Thygesen K, Alpert JS, Allan S, et al. Third universal definition of myocardial infarction. Circulation. 2012;60:1581-1598.

Muschart X, Slimani A, Jamart J, et al. The different mechanisms of periprocedural myocardial infarction and their impact on in-hospital outcome. J Invasive Cardiol. 2012;24:655-660.

Leonardi S, Armstrong PW, Schulte PJ, et al. Implementation of standardized assessment and reporting of myocardial infarction in contemporary randomized controlled trials: A systematic review. Eur Heart J. 2013;34:894-902.

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