Ovarian cancer, as the malignant tumor with the highest mortality rate in gynecological tumors. At present, the main treatment for ovarian cancer is the combination of cytoreduction surgery and chemotherapy. But the surgery is insufficient to solve extensive transfer of tumor in the abdominal cavity. Similarly, large proportion of ovarian cancer cases have shown resistance to chemotherapy. Photodynamic therapy (PDT) has been widely used in disease, especially malignant tumors and as the most widely used photosensitive agents, porphyrin sensitizers have following advantages: short photosensitive period and high singlet oxygen production. However, most studies have found that it is difficult to achieve high loading rates of photosensitive agents, thus effective concentration in target tissue can’t be ideal and the lethal ability is greatly reduced. In this article, we review studies that nanoparticles loading porphyrin sensitizers for photodynamic therapy of ovarian cancer.
We collected relevant literatures from PUBMED and reviewed their research content.
The application of nanotechnology to PDT in ovarian cancer can reduce the nonspecific toxicity of photosensitive agents and increase stability and delivery efficiency.
The combination with nanotechnology can improve the shortcomings of photodynamic therapy, the specific efficacy still needs a large number of experiments to prove.

Copyright © 2020. Published by Elsevier B.V.

References

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