The following is a summary of “Examination of host genetic effects on nasal microbiome composition,” published in the NOVEMBER 01, 2022 issue of Allergy and Clinical Immunology by Irizar, et al.
Asthma risk is increased by a genetic predisposition, and the condition is linked to certain nasal microbial compositions. Nasal microbiome composition may be influenced by host genetics. For a study, researchers looked for links between the host’s genetic makeup and the nasal microbiome’s makeup.
Over 584 people from the Mount Sinai Health System in New York provided nasal samples. From a subset of 40 subjects, 77 follow-up samples were obtained. Nasal sample analysis included RNA and 16S rRNA sequencing. Variant calling on RNA sequencing data was done, beta diversity was computed, and genetic relatedness between individuals was assessed. They looked for correlations between nasal microbiota makeup and genetic relatedness using linear regression models.
The cohort’s members represented a variety of ancestries, and 52.7% of the cohort was female. The cohort’s median age was 14.6 years (interquartile range: 11.2-19.5). The median interval between samples for those who offered follow-up samples was 5.1 (interquartile range: 1.4–7.2) months. Beta diversity, which measures nasal microbiota composition similarity, was substantially higher among participants over time than between subjects (coefficient = 0.091, P = 2.84-7). Beta diversity and genetic relatedness did not significantly correlate (coefficient = -0.05, P=.29). Similar findings were obtained from further analyses examining the connection between genetic variation and beta diversity.
The makeup of the nasal microbiome was not greatly influenced by host genetics.