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Neural control of blood pressure in women: differences according to age.

Neural control of blood pressure in women: differences according to age.
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Peinado AB, Harvey RE, Hart EC, Charkoudian N, Curry TB, Nicholson WT, Wallin BG, Joyner MJ, Barnes JN,


Peinado AB, Harvey RE, Hart EC, Charkoudian N, Curry TB, Nicholson WT, Wallin BG, Joyner MJ, Barnes JN, (click to view)

Peinado AB, Harvey RE, Hart EC, Charkoudian N, Curry TB, Nicholson WT, Wallin BG, Joyner MJ, Barnes JN,

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Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2017 02 16() doi 10.1007/s10286-017-0403-0
Abstract
PURPOSE
The blood pressure "error signal" represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the "T50"). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause.

METHODS
We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 ± 1 years) and 12 postmenopausal women (61 ± 2 years) before and during complete autonomic blockade with trimethaphan camsylate.

RESULTS
At baseline, young women had a negative error signal (-8 ± 1 versus 2 ± 1 mmHg, p < 0.001; respectively) and lower muscle sympathetic nerve activity (15 ± 1 versus 33 ± 3 bursts/min, p < 0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r = -0.725, p = 0.008) but not in young women (r = -0.337, p = 0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r = 0.886, p < 0.001; older: r = 0.870, p < 0.001). CONCLUSIONS
Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

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