Advertisement

 

 

Neural Hyperexcitability in Autism Spectrum Disorders.

Neural Hyperexcitability in Autism Spectrum Disorders.
Author Information (click to view)

Takarae Y, Sweeney J,


Takarae Y, Sweeney J, (click to view)

Takarae Y, Sweeney J,

Advertisement

Brain sciences 2017 10 137(10) pii E129
Abstract

Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed.

Submit a Comment

Your email address will not be published. Required fields are marked *

12 + six =

[ HIDE/SHOW ]