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Neuronal surface antibodies in HIV-infected patients with isolated psychosis.

Neuronal surface antibodies in HIV-infected patients with isolated psychosis.
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Cunill V, Arboleya S, Jiménez ML, Campins A, Herbera P, Mestre L, Clemente A, Barceló MI, Leyes M, Canellas F, Julià MR,


Cunill V, Arboleya S, Jiménez ML, Campins A, Herbera P, Mestre L, Clemente A, Barceló MI, Leyes M, Canellas F, Julià MR, (click to view)

Cunill V, Arboleya S, Jiménez ML, Campins A, Herbera P, Mestre L, Clemente A, Barceló MI, Leyes M, Canellas F, Julià MR,

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Journal of neuroimmunology 2016 11 02301() 49-52 pii 10.1016/j.jneuroim.2016.10.008

Abstract

Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort. In the retrospective analysis, 22% of NSA-positive versus 4.6% of negative patients were HIV-positive. Wider studies are required to clarify the relationship between NSA and HIV infection.

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