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Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study.

Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study.
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Acosta I, Borges G, Aguirre-Hernandez R, Sosa AL, Prince M, ,


Acosta I, Borges G, Aguirre-Hernandez R, Sosa AL, Prince M, , (click to view)

Acosta I, Borges G, Aguirre-Hernandez R, Sosa AL, Prince M, ,

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Alzheimer’s & dementia : the journal of the Alzheimer’s Association 2017 10 10() pii S1552-5260(17)33718-4
Abstract
INTRODUCTION
Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence.

METHODS
We analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow-up, modeling cumulative incidence ratios using Poisson models.

RESULTS
Five neuropsychiatric symptoms were associated with incident dementia: delusions, hallucinations, anxiety, aberrant motor behavior, and depression. The simultaneous presence of two symptoms had a relative risk, adjusted for mild cognitive impairment, diabetes, indicators of cognitive function, and sociodemographic factors, of 1.9 (95% confidence interval, 1.2-2.9), whereas the presence of three to five, similarly adjusted, had a relative risk of 3.0 (95% confidence interval, 1.9-4.8).

DISCUSSION
Neuropsychiatric symptoms are common in predementia states and may independently contribute as risk factors for developing dementia.

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