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New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis.

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis.
Author Information (click to view)

Wu MY, Li CJ, Hou MF, Chu PY,


Wu MY, Li CJ, Hou MF, Chu PY, (click to view)

Wu MY, Li CJ, Hou MF, Chu PY,

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International journal of molecular sciences 2017 09 2218(10) pii E2034
Abstract

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local inflammation. Immune and inflammatory responses have significant effects on every phase of atherosclerosis, and increasing evidence shows that immunity plays a more important role in atherosclerosis by tightly regulating its progression. Therefore, understanding the relationship between immune responses and the atherosclerotic microenvironment is extremely important. This article reviews existing knowledge regarding the pathogenesis of immune responses in the atherosclerotic microenvironment, and the immune mechanisms involved in atherosclerosis formation and activation.

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