Night-to-night variability of obstructive sleep apnea severity (OSA) is considerable and may depend on the diagnostic modality used. We investigated the night-to-night variability using peripheral arterial tonometry (PAT).
Home sleep apnea testing was performed in 51 patients during three consecutive nights using PAT. Patients referred to our sleep clinic were screened and prospectively recruited for this study. All recordings were automatically and manually scored according to the PAT scoring guidelines.
No systematic differences in pAHI were found between the nights. The night-to-night variability was comparable between manually and automatically scored data. PAT-derived apnea-hypopnea index (pAHI) varied in 35% of patients more than 10/h between the nights. The OSA severity of 24% of patients was misclassified when using one night compared to the average of all nights. On average, pAHI varied by 57% from night-to-night. The variability of pAHI could partially be explained by the variability of time spent in the supine position with more time supine leading to a higher pAHI. On measuring a subsequent night, 12-14% of patients spontaneously fulfilled the commonly accepted criteria for treatment success without any intervention.
With repeated recordings of PAT, we found no first night effect. However, there is considerable night-to-night variability similar to values found for polysomnography, which can partially be explained by the variability of time spent in the supine position. OSA severity was frequently misclassified due to the night-to-night variability. Our findings make a strong case for multiple testing in the diagnostic work-up of OSA patients.

© 2021 American Academy of Sleep Medicine.

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