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NMDAR-Independent Hippocampal Long-Term Depression Impairment after Status Epilepticus in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.

NMDAR-Independent Hippocampal Long-Term Depression Impairment after Status Epilepticus in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.
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Ivanov AD, Zaitsev AV,


Ivanov AD, Zaitsev AV, (click to view)

Ivanov AD, Zaitsev AV,

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Synapse (New York, N.Y.) 2017 04 22() doi 10.1002/syn.21982
Abstract

Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits. Despite numerous existing studies on various animal models, the mechanisms of these deficits remain largely unclear. A specific form of long-term synaptic efficacy changes – long-term depression (LTD) – is thought to play an important role in memory formation and learning. However, extremely little is known about the possible alteration of LTD induction and dynamics after a status epilepticus (SE). In the present work we investigated the acute and delayed effects of lithium-pilocarpine-induced SE on NMDAR-dependent and NMDAR-independent hippocampal LTD in vitro. We found that SE affected the NMDAR-dependent and NMDAR-independent forms of LTD in different manners. The NMDAR-dependent form of LTD was almost intact 3 days after SE, but it switched from a predominantly presynaptic to a more postsynaptic locus of expression. In contrast, the NMDAR-independent LTD in the hippocampal Schaffer collaterals-CA1 synapses was fully abolished 3 days after SE. Our results emphasize the role of non-NMDA-dependent synaptic plasticity changes in the processes of epileptogenesis and the potential for therapy development. This article is protected by copyright. All rights reserved.

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