The level of calcium in the blood serum, voice function, thyroid status and quality of life of patients up to 1 year after removal of the thyroid gland were studied. Thyroidectomy is an operation associated with a high risk of postoperative hypocalcemia with clinical manifestations (19.6%), which is transient in 15.5%, and permanent in 4.1%. After thyroidectomy transient voice disorders are observed that are not associated with paresis of the laryngeal nerves. These voice disorders spontaneously resolve in the period from 2 to 6 months after the operation. The effectiveness and safety of therapy for postoperative hypothyroidism, the correct selection of the dose of L-thyroxine depends not only on the level of TSH, but also on the genetic characteristics of the patient. Pharmacogenetic testing allows predicting the effectiveness of hypothyroidism correction. The quality of life after thyroidectomy is generally worse than after organ-preserving operations. To a large extent, it is determined by hypothyroidism. In the long term, the quality of life after thyroidectomy approaches the estimates of patients after organ-preserving operations. For an adequate assessment of the results of the operation, it is necessary to analyze the results no earlier than 1 year later.

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