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November 2017 Briefing – Pathology

November 2017 Briefing – Pathology
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Here are what the editors at HealthDay consider to be the most important developments in Pathology for November 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Physicians Report High Rate of Uncontrolled Atopic Dermatitis

THURSDAY, Nov. 30, 2017 (HealthDay News) — Physicians rate a high proportion of patients with atopic dermatitis (AD) as having inadequate disease control, according to a study published online Nov. 13 in the Journal of Dermatology.

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Incidence of HIV Dropped From 1999 to 2016 in Uganda

THURSDAY, Nov. 30, 2017 (HealthDay News) — The incidence of HIV infection declined significantly in Uganda between 1999 and 2016, according to a study published in the Nov. 30 issue of the New England Journal of Medicine.

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More Than Half Today’s Children Expected to Be Obese at 35

THURSDAY, Nov. 30, 2017 (HealthDay News) — More than half of today’s children are expected to be obese at the age of 35 years, with about half of the prevalence occurring during childhood, according to a study published in the Nov. 30 issue of the New England Journal of Medicine.

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Mortality Up for Some Cancers in Urban-Dwelling Native Americans

THURSDAY, Nov. 30, 2017 (HealthDay News) — Urban American Indians and Alaskan Natives (AIAN) with cancer have a significantly higher comorbidity burden, and have higher mortality for some cancers, according to a study published online Nov. 29 in Cancer Research.

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Magnesium Boosts Environmental Enrichment in Alzheimer’s

THURSDAY, Nov. 30, 2017 (HealthDay News) — The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer’s disease (AD), according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.

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Recommendations Developed for Lymphangioleiomyomatosis

WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Evidence-based recommendations have been developed for the diagnosis and treatment of patients with lymphangioleiomyomatosis (LAM), and published in the Nov. 15 issue of the American Journal of Respiratory and Critical Care Medicine.

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Endocrine-Disrupting Chemicals Linked to Diabetes Disparities

WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Disparities in exposure to diabetes-associated environmental endocrine-disrupting chemicals (EDCs) may contribute to disparities in diabetes, according to a review published online Nov. 15 in Diabetes Care.

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Over 5 Percent of Incident Cancer Due to Diabetes, High BMI

WEDNESDAY, Nov. 29, 2017 (HealthDay News) — More than 5 percent of all incident cancers in 2012 were attributable to diabetes and high body mass index (BMI), according to a study published online Nov. 28 in The Lancet Diabetes & Endocrinology.

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Fecal Microbial Transplant by Oral Capsule Noninferior for CDI

WEDNESDAY, Nov. 29, 2017 (HealthDay News) — For patients with recurrent Clostridium difficile infection (RCDI), fecal microbial transplantation (FMT) with oral capsules is noninferior to FMT by colonoscopy, according to a study published in the Nov. 28 issue of the Journal of the American Medical Association.

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Cord Blood Improves Motor Function With Cerebral Palsy

WEDNESDAY, Nov. 29, 2017 (HealthDay News) — Infusion of autologous umbilical cord blood improves whole brain connectivity and motor function in young children with cerebral palsy (CP), according to a study published online Oct. 28 in Stem Cells Translational Medicine.

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Measuring Plasma PCSK9 May ID Resistance to PCSK9 Inhibitors

TUESDAY, Nov. 28, 2017 (HealthDay News) — Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors, according to a research letter published online Nov. 28 in the Annals of Internal Medicine.

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CDC: HIV Being Diagnosed Sooner After Infection

TUESDAY, Nov. 28, 2017 (HealthDay News) — HIV is being diagnosed sooner after infection than previously reported, according to a Nov. 28 press release issued by the U.S. Centers for Disease Control and Prevention.

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Less Frequent Biopsy May Be Option in Prostate Cancer Care

TUESDAY, Nov. 28, 2017 (HealthDay News) — Biennial biopsies are an acceptable alternative to annual biopsies for men managing low-risk prostate cancer through active surveillance (AS), according to a research published online Nov. 27 in the Annals of Internal Medicine.

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Escalation Noted in Incidence of Scarlet Fever in England

TUESDAY, Nov. 28, 2017 (HealthDay News) — There has been a recent escalation in the incidence of scarlet fever in England, according to a study published online Nov. 27 in The Lancet Infectious Diseases.

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1998 to 2014 Saw Drop in CVD Hospitalization Rates in Diabetes

TUESDAY, Nov. 28, 2017 (HealthDay News) — Cardiovascular disease (CVD) hospitalization rates have declined in recent years among individuals with and those without diabetes, according to a study published online Nov. 17 in Diabetes Care.

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Simple ECG May Help Distinguish MDD From Bipolar Depression

TUESDAY, Nov. 28, 2017 (HealthDay News) — Heart rate variability (HRV) and specific inflammatory biomarkers can differentiate major depressive disorder (MDD) from depression in bipolar disorder (BD), according to a study published online Oct. 5 in The World Journal of Biological Psychiatry.

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Risk of ≥CIN3 Drops With Negative HPV, Cytology Co-Tests

TUESDAY, Nov. 28, 2017 (HealthDay News) — The five-year risks of cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ, and cervical cancer (≥CIN3) decrease after each successive negative human papillomavirus (HPV) and cytology co-testing, according to a study published online Nov. 27 in the Annals of Internal Medicine.

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Sex, Race, Age Disparities in Survival for HPV-Linked Cancer

TUESDAY, Nov. 28, 2017 (HealthDay News) — For patients with human papillomavirus (HPV)-associated cancers, there are large disparities in survival based on sex, race, and age, according to a study published online Nov. 6 in Cancer.

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Considerable Costs Incurred in Response to Single Measles Cases

MONDAY, Nov. 27, 2017 (HealthDay News) — Single measles cases trigger coordinated public health action that is associated with considerable costs, according to research published in the Nov. 24 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

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Essay Adds to Discourse on Impact of Suggestive Jokes

MONDAY, Nov. 27, 2017 (HealthDay News) — Seemingly benign, recurring patterns of joking around a single theme (joke cycles) can contribute to humorizing and legitimizing sexual misconduct, according to an essay published online Nov. 12 in Communication and Critical/Cultural Studies.

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New Workflows Have Potential to Address Provider Burnout

MONDAY, Nov. 27, 2017 (HealthDay News) — New solutions are needed to address burnout among health care team members, yet, in a catch-22 situation for health industry leaders, change fatigue contributes to burnout, according to a Vocera Communications report entitled In Pursuit of Resilience, Well-Being, and Joy in Healthcare.

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Genetic Variants Tied to Type 1 Diabetes Heterogeneity

MONDAY, Nov. 27, 2017 (HealthDay News) — Transcription factor 7 like 2 (TCF7L2) genetic variants contribute to phenotypic heterogeneity of type 1 diabetes, according to a study published online Oct. 12 in Diabetes Care.

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Clinician Suspicion Minimally Accurate for Lyme Disease

MONDAY, Nov. 27, 2017 (HealthDay News) — Clinician suspicion has minimal accuracy for the diagnosis of Lyme disease, according to a study published online Nov. 24 in Pediatrics.

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Vitamin E in Early Childhood Tied to Lower ALT Levels Later

MONDAY, Nov. 27, 2017 (HealthDay News) — Higher early childhood intake of alpha-tocopherol is associated with lower odds of elevated mid-childhood alanine aminotransferase (ALT) levels, according to a study published online Nov. 9 in Hepatology.

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History of Prior Cancer Common in Newly Diagnosed Patients

MONDAY, Nov. 27, 2017 (HealthDay News) — A substantial number of patients diagnosed with incident cancer in the United States have a prior history of cancer, according to a brief report published online Nov. 22 in JAMA Oncology.

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NTproBNP Levels Are Significantly Lower in Blacks

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) levels are significantly lower for black than white individuals, according to a study published online Nov. 22 in JAMA Cardiology.

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Raw Flour Can Be Source of Shiga Toxin-Producing E. coli

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Raw flour can be a source of outbreak of Shiga toxin-producing Escherichia coli (STEC) infections, according to a study published in the Nov. 23 issue of the New England Journal of Medicine.

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Female Physicians’ Spouses More Likely to Work

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Spouses of female physicians are on average more educated and work more hours outside the home than spouses of male physicians, according to a research letter published online Nov. 21 in the Annals of Internal Medicine.

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Monoclonal Antibodies Cut Ischemia-Reperfusion Injury

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Anti-CD47 monoclonal antibody (CD47mAb) therapy reduces ischemia-reperfusion injury of renal allografts in an animal transplantation model, according to a study published online Oct. 31 in the American Journal of Transplantation.

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Maternal GDM Tied to Child’s Cardiometabolic Profile

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Teenage offspring of mothers with gestational diabetes mellitus (GDM) have increased adiposity and an adverse cardiometabolic profile, according to a study published online Oct. 16 in Diabetes Care.

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Researchers ID Microbiome Genes Tied to Asthma

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Functional genes in the upper airway microbiome may be tied to childhood asthma, according to a study published Nov. 20 in Allergy.

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CDC Issues Warning on Contaminated Raw Milk

WEDNESDAY, Nov. 22, 2017 (HealthDay News) — Individuals who may have consumed contaminated raw milk and milk products from the Udder Milk company are urged to seek medical care, according to a report published by the U.S. Centers for Disease Control and Prevention.

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Insulin Doesn’t Prevent Diabetes in Relatives of T1DM Patients

TUESDAY, Nov. 21, 2017 (HealthDay News) — Oral insulin does not delay onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes, according to a study published in the Nov. 21 issue of the Journal of the American Medical Association.

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High Costs Associated With Physician Burnout, Attrition

TUESDAY, Nov. 21, 2017 (HealthDay News) — Physicians who are experiencing burnout are more than twice as likely to leave their organization within two years, and this is associated with significant economic costs, according to a report from the American Medical Association.

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Doubts Raised About Use of Products Containing Oxybenzone

TUESDAY, Nov. 21, 2017 (HealthDay News) — Use of oxybenzone (Benzophenone-3) in sunscreen and personal care products should be minimized due to its dermatological and environmental toxicity, according to a review published online Oct. 31 in the Journal of Cosmetic Dermatology.

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Best Practice Advice Issued for Hep B Vaccination, Screening

TUESDAY, Nov. 21, 2017 (HealthDay News) — Best practice advice statements from the American College of Physicians and the U.S. Centers for Disease Control and Prevention, published online Nov. 21 in the Annals of Internal Medicine, encourage hepatitis B virus (HBV) screening in high-risk populations, vaccination of all unvaccinated at-risk adults, and linkage to care for HBV-positive patients.

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Stool-Based Protein Combos Can Improve CRC Screening

TUESDAY, Nov. 21, 2017 (HealthDay News) — Combinations of four proteins from stool samples can detect colorectal cancer (CRC) and advanced adenomas with higher sensitivity than hemoglobin alone, according to a study published online Nov. 21 in the Annals of Internal Medicine.

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NOACs Show Lower Risk of Adverse Renal Outcomes in A-Fib

TUESDAY, Nov. 21, 2017 (HealthDay News) — For patients with atrial fibrillation (AF), non-vitamin K antagonist oral anticoagulants (NOACs) are associated with lower risks of adverse renal outcomes than warfarin, according to a study published in the Nov. 28 issue of the Journal of the American College of Cardiology.

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Salivary miRNAs Can ID Duration of Concussion Symptoms

MONDAY, Nov. 20, 2017 (HealthDay News) — For children with concussion, salivary microRNAs (miRNAs) can accurately identify the duration of symptoms, according to a study published online Nov. 20 in JAMA Pediatrics.

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High Salt Intake Impacts Gut Microbiome

MONDAY, Nov. 20, 2017 (HealthDay News) — High salt intake affects the gut microbiome; however, certain intestinal bacteria may help prevent high-salt diets contributing to hypertension, according to research published online Nov. 15 in Nature.

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Certain Traits Tied to More HIV Tests in Transgender Individuals

MONDAY, Nov. 20, 2017 (HealthDay News) — Transgender individuals with certain characteristics, including a history of incarceration and self-referral, have more HIV tests, according to a short report published in Transgender Health.

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Fat Distribution May Influence Bone Strength in Adolescence

MONDAY, Nov. 20, 2017 (HealthDay News) — Visceral adipose tissue (VAT) in girls and central adiposity in boys play a role in the acquisition of bone strength during adolescence, according to a study published online Oct. 30 in the Journal of Bone and Mineral Research.

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Brain Glucose Responses Diminish With Diabetes, Obesity

MONDAY, Nov. 20, 2017 (HealthDay News) — The rise of brain glucose levels is blunted during hyperglycemia in adults with obesity and type 2 diabetes mellitus (T2DM), according to a study published online Oct. 19 in JCI Insight.

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NAFLD Linked to Increased Cancer Incidence Rate

MONDAY, Nov. 20, 2017 (HealthDay News) — Non-alcoholic fatty liver disease (NAFLD) is associated with development of cancer, specifically hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females, according to a study published online Nov. 14 in the Journal of Hepatology.

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Distinct Features for Drug Use-Related Endophthalmitis

MONDAY, Nov. 20, 2017 (HealthDay News) — Patients with injection drug use (IDU) endogenous endophthalmitis (EE) are younger, with fewer comorbidities, and have more improvement in visual acuity after intervention compared with non-IDU EE patients, according to a research letter published online Nov. 16 in JAMA Ophthalmology.

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Many Health Care Providers Work While Sick

FRIDAY, Nov. 17, 2017 (HealthDay News) — More than 40 percent of health care personnel (HCP) with influenza-like illness (ILI) work while ill, according to a study published in the November issue of the American Journal of Infection Control.

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Simple Checklist Can Identify Useful Clinical Practice Guidelines

FRIDAY, Nov. 17, 2017 (HealthDay News) — A simple, easy-to-use checklist, the Guideline Trustworthiness, Relevance, and Utility Scoring Tool (G-TRUST), can identify useful clinical practice guidelines, according to a study published in the September/October issue of the Annals of Family Medicine.

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AMD Risk Has Dropped By Birth Cohort Throughout 20th Century

FRIDAY, Nov. 17, 2017 (HealthDay News) — There was a decrease in the five-year risk for age-related macular degeneration (AMD) by birth cohorts throughout the 20th century, according to a study published online Nov. 16 in JAMA Ophthalmology.

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FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

FRIDAY, Nov. 17, 2017 (HealthDay News) — Hemlibra (emicizumab-kxwh) has been approved by the U.S. Food and Drug Administration to prevent or reduce the frequency of bleeding episodes among hemophilia A patients with Factor VIII inhibitors.

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Heterogeneity of PET/CT Imaging Phenotype Prognostic in mCRPC

THURSDAY, Nov. 16, 2017 (HealthDay News) — Metastatic castration-resistant prostate cancer (mCRPC) has heterogeneity in positron emission tomography (PET)/computed tomography (CT) imaging phenotype, which has clinical relevance, according to a study published online Nov. 9 in JAMA Oncology.

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Simpler Tool Promising for Atherosclerosis Prediction

THURSDAY, Nov. 16, 2017 (HealthDay News) — The ideal cardiovascular health score (ICHS) and the Fuster-BEWAT (blood pressure, exercise, weight, alimentation, and tobacco) score (FBS) are similar in their ability to predict subclinical atherosclerosis, according to a study published online Nov. 13 in the Journal of the American College of Cardiology.

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Model Predicts Development of Chronic Kidney Disease

THURSDAY, Nov. 16, 2017 (HealthDay News) — A multivariable model that uses routine laboratory data is able to predict advanced chronic kidney disease after hospitalization with acute kidney injury, according to a study published online Nov. 14 in the Journal of the American Medical Association.

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Accurate Diagnosis Seen With Photographs of Skin Conditions

THURSDAY, Nov. 16, 2017 (HealthDay News) — Smartphone photographs of pediatric skin conditions taken by parents are of sufficient quality to allow accurate diagnosis, according to a study published online Nov. 15 in JAMA Dermatology.

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Sentinel Lymph Node Biopsy Underused in High-Risk SCC

THURSDAY, Nov. 16, 2017 (HealthDay News) — Sentinel lymph node biopsy (SLNB) is underused for high-risk squamous cell carcinoma (SCC) of the skin, according to a research letter published online Nov. 15 in JAMA Dermatology.

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In 2007-2014, Glycemic Control Plateaued in Diabetes Patients

WEDNESDAY, Nov. 15, 2017 (HealthDay News) — Despite increases in HbA1c testing and awareness, glycemic control seems to have plateaued among patients with diabetes between 2007 and 2014, according to a research letter published online Nov. 14 in the Journal of the American Medical Association.

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ER- Breast CA Risk Up for African-Americans With T2DM

WEDNESDAY, Nov. 15, 2017 (HealthDay News) — African-American (AA) women with type 2 diabetes (T2D) appear to be at increased risk of developing estrogen receptor-negative (ER-) breast cancer, with the highest risk among nonobese individuals, according to a study published online Nov. 15 in Cancer Research.

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More Laboratory Tests Performed at Major Teaching Hospitals

TUESDAY, Nov. 14, 2017 (HealthDay News) — For inpatients with a primary diagnosis of bacterial pneumonia or cellulitis, significantly more laboratory tests are performed per day at major teaching hospitals versus nonteaching hospitals, according to a study published online Nov. 13 in JAMA Internal Medicine.

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LRRK2 Variants Linked to Lower Age at Onset of Parkinson’s

TUESDAY, Nov. 14, 2017 (HealthDay News) — The presence of multiple LRRK2 risk variants is associated with a younger age at onset (AAO) of Parkinson’s disease (PD), according to a research letter published online Nov. 13 in JAMA Neurology.

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Outbreaks Linked to Drinking Water Mainly Due to Legionella

TUESDAY, Nov. 14, 2017 (HealthDay News) — Most drinking water-associated waterborne disease outbreaks and waterborne disease outbreaks associated with environmental or undetermined exposure to water are due to Legionella, according to two studies published online Nov. 9 in Morbidity and Mortality Weekly Report.

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Use of MMR Deficiency Testing in Younger CRC Patients Is Low

MONDAY, Nov. 13, 2017 (HealthDay News) — Fewer than half of younger adults with colorectal cancer (CRC) undergo mismatch repair (MMR) deficiency of DNA testing, according to a study published online Nov. 9 in JAMA Oncology.

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About 20 Percent of U.S. Adults Currently Use Tobacco Products

MONDAY, Nov. 13, 2017 (HealthDay News) — About one in five U.S. adults currently uses any tobacco product, according to a study published online Nov. 9 in Morbidity and Mortality Weekly Report.

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Soluble Interleukin 2 Receptor IDs Sarcoidosis in Uveitis

MONDAY, Nov. 13, 2017 (HealthDay News) — Soluble interleukin 2 receptor (sIL-2R) has slightly better diagnostic value than angiotensin-converting enzyme (ACE) for sarcoidosis in patients with uveitis, according to a study published online Nov. 9 in JAMA Ophthalmology.

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Cardiac Index Linked to Cerebral Blood Flow Regardless of CVD

MONDAY, Nov. 13, 2017 (HealthDay News) — Among older adults, lower cardiac index is associated with lower resting cerebral blood flow (CBF) in the temporal lobes regardless of cardiovascular disease (CVD) but is not associated with cerebrovascular reactivity (CVR), according to a study published online Nov. 8 in Neurology.

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Eclampsia Tied to Increased Relative Risk of Seizure Disorder

THURSDAY, Nov. 9, 2017 (HealthDay News) — The relative risk of a seizure disorder after eclampsia is higher than that of women unaffected by eclampsia but remains extremely low, according to a study published online Nov. 7 in Obstetrics & Gynecology.

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Breast Cancer Recurrences Steady After Therapy Cessation

THURSDAY, Nov. 9, 2017 (HealthDay News) — When adjuvant endocrine therapy for estrogen receptor-positive breast cancer is stopped after five years, recurrences occur at a steady rate into the future, according to a meta-analysis published online Nov. 8 in the New England Journal of Medicine.

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Adipocytes Metabolize, Inactivate Daunorubicin

THURSDAY, Nov. 9, 2017 (HealthDay News) — Adipocytes metabolize and inactivate the anthracycline daunorubicin, according to a study published online Nov. 8 in Molecular Cancer Research.

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Vaccination Coverage High for Children Aged 19 to 35 Months

THURSDAY, Nov. 9, 2017 (HealthDay News) — Vaccination coverage has remained above 90 percent for many vaccinations among young children, and progress is being made toward immunization information systems (IISs) program goals, according to two studies published online Nov. 2 in Morbidity and Mortality Weekly Report.

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Benefits for New Immunoassays for Measuring Aβ42 in CSF

THURSDAY, Nov. 9, 2017 (HealthDay News) — Concentrations of cerebrospinal fluid (CSF) β42-amyloid 42 (Aβ42) derived from new immunoassays may show improved agreement with visual flutemetamol F18 ([18F]flutemetamol)-labeled positron emission tomography (PET) assessment, according to a study published online Nov. 6 in JAMA Neurology.

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Risk of End-Stage Renal Disease Low With Type 1 Diabetes

THURSDAY, Nov. 9, 2017 (HealthDay News) — Among patients with childhood-onset type 1 diabetes, there is a very low incidence of end-stage renal disease (ESRD), according to a Norwegian study published online October 12 in Diabetes Care.

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Doctors Have Extra Two Weeks to Preview Performance Data

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Physicians have two extra weeks to preview their 2016 performance information as a result of a mistake related to the Centers for Medicare & Medicaid Services’ Physician Compare online resource, according to a report published by the American Academy of Family Physicians.

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Hearing Loss Among U.S. Adolescents Is Not Increasing

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Hearing loss among U.S. adolescents seems not to be increasing, according to a study published online Nov. 8 in Pediatrics.

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Glycosylation Differences in Egg-Adapted Vaccines May Cut Impact

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Differences in glycosylation between H3N2 egg-adapted vaccines and circulating strains probably reduced vaccine effectiveness during the 2016-2017 influenza season, according to a study published online Nov. 6 in the Proceedings of the National Academy of Sciences.

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ASCO Issues Statement Regarding Alcohol and Cancer

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Alcohol use is associated with certain types of cancer, and the risk of cancer can be reduced by strategies to prevent excessive use of alcohol, according to a statement published online Nov. 7 in the Journal of Clinical Oncology.

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Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — For patients with inflammatory bowel disease (IBD), the risk of lymphoma is increased with use of thiopurine monotherapy, anti-tumor necrosis factor (TNF) monotherapy, and combination therapy, according to a study published online Nov. 7 in the Journal of the American Medical Association.

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Drop in Incidence of End-Stage Renal Disease Due to Diabetes

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — The incidence of end-stage renal disease (ESRD) with diabetes listed as the primary cause (ESRD-D) decreased across the United States from 2000 to 2014, according to a study published online Nov. 2 in Morbidity and Mortality Weekly Report.

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Increases in U.S. Health Spending Tied to Health Service Price

WEDNESDAY, Nov. 8, 2017 (HealthDay News) — Factors including increases in health care service price and intensity are associated with increases in U.S. health care spending from 1996 to 2013, according to a study published online Nov. 7 in the Journal of the American Medical Association.

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Intensity of Exercise Affects Impact on Mortality Risk

TUESDAY, Nov. 7, 2017 (HealthDay News) — Total physical activity (PA) and moderate- to vigorous-intensity PA (MVPA) are inversely associated with mortality, though light-intensity PA and sedentary behavior are not associated with mortality, according to a research letter published online Nov. 6 in Circulation.

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Brain Measures Tied to Atrial Pressure in Valvular Heart Dz

TUESDAY, Nov. 7, 2017 (HealthDay News) — For patients with chronic valvular heart disease, white matter hyperintensity (WMH) volume is associated with mean right atrial (RA) pressure, according to a study published online Nov. 6 in JAMA Neurology.

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Lifestyle Changes Successfully Reduce Incidence of Diabetes

TUESDAY, Nov. 7, 2017 (HealthDay News) — Lifestyle modification (LSM) and medications can reduce the incidence of diabetes in adults at risk, although the effects of medications are short-lived, according to a review published online Nov. 6 in JAMA Internal Medicine.

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ASN: Promising Diagnostic Marker for Fibrillary GN Identified

MONDAY, Nov. 6, 2017 (HealthDay News) — Researchers have identified a potential diagnostic and therapeutic target for fibrillary glomerulonephritis (FGN), according to two studies published online Nov. 2 in the Journal of the American Society of Nephrology to coincide with presentation at the annual meeting of the American Society of Nephrology, being held Oct. 31 to Nov. 5 in New Orleans.

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Fiber Tied to Lower Mortality in Those With Colorectal Cancer

MONDAY, Nov. 6, 2017 (HealthDay News) — Higher fiber intake after a diagnosis of nonmetastatic colorectal cancer (CRC) is associated with lower CRC-specific and overall mortality, according to a study published online Nov. 2 in JAMA Oncology.

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Novel Method Developed for Estimating Prevalence of Diabetes

MONDAY, Nov. 6, 2017 (HealthDay News) — A novel method has been developed to enhance the prevalence estimates of diabetes and prediabetes, according to a study published online Nov. 2 in Preventing Chronic Diseases.

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Incidence of Early-Stage Breast CA, CRC Up With ACA Adoption

MONDAY, Nov. 6, 2017 (HealthDay News) — After adoption of the Affordable Care Act (ACA), there was an increase in the incidence of early-stage breast and colorectal cancer, according to a research letter published online Nov. 2 in JAMA Oncology.

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Cases of Low Vision, Blindness Estimated to Double in 30 Years

FRIDAY, Nov. 3, 2017 (HealthDay News) — Prevalence and incidence rates of low vision and blindness demonstrate a growing need for low vision rehabilitation services in the United States, according to a study published online Nov. 2 in JAMA Ophthalmology.

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Almost One in Four Skin Biopsies Is Melanocytic Proliferation

FRIDAY, Nov. 3, 2017 (HealthDay News) — About one-quarter of skin biopsies are diagnosed as melanocytic proliferation, according to a study published online Nov. 1 in JAMA Dermatology.

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Inflammatory Biomarkers May Impact Risk of Schizophrenia

THURSDAY, Nov. 2, 2017 (HealthDay News) — Specific inflammatory biomarkers may impact the risk of developing schizophrenia, with a protective effect noted for C-reactive protein (CRP) and a risk-increasing effect for soluble interleukin-6 receptor (sIL-6R), according to a study published online Nov. 1 in JAMA Psychiatry.

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Midlife Systemic Inflammation Tied to Late-Life Brain Volume

THURSDAY, Nov. 2, 2017 (HealthDay News) — Systemic inflammation in midlife is associated with future neurodegeneration and cognitive aging, according to a study published online Nov. 1 in Neurology.

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Race a Factor in Intracranial Atherosclerotic Disease

THURSDAY, Nov. 2, 2017 (HealthDay News) — Black men have increased prevalence and frequency of multiple intracranial atherosclerotic plaques, according to a study published online Nov. 1 in JAMA Cardiology.

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PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors

THURSDAY, Nov. 2, 2017 (HealthDay News) — PARP inhibitors demonstrate activity in triple-negative breast cancer (TNBC) tumors without BRCA1/2 mutations, according to a study published online Nov. 1 in Clinical Cancer Research.

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Driving Impairment Warnings Often Not Given With Rx Meds

THURSDAY, Nov. 2, 2017 (HealthDay News) — Not all prescription drug users report receiving warnings about driving impairment, according to a study published online Nov. 1 in the Journal of Studies on Alcohol and Drugs.

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GLP-1 May Mediate Effects of Gastric Bypass on CNS Activation

THURSDAY, Nov. 2, 2017 (HealthDay News) — The central effects of glucagon-like peptide-1 (GLP-1) may mediate the effects of Roux-en-Y gastric bypass (RYGB) on central nervous system (CNS) activation in response to visual and gustatory food cues, according to a study published online Oct. 12 in Diabetes Care.

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CMS Launches Initiative to Examine Impact of Regulations

WEDNESDAY, Nov. 1, 2017 (HealthDay News) — The Centers for Medicare & Medicaid Services (CMS) has launched an initiative to examine which provider regulations should be discarded or revamped amid concerns that the regulations are reducing the amount of time that physicians spend with patients, according to an article published in Modern Healthcare.

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Hepatitis B Viral Load, Surface Antigen May ID Liver Cancer Risk

WEDNESDAY, Nov. 1, 2017 (HealthDay News) — Elevated levels of hepatitis B virus (HBV) DNA and hepatitis B surface antigen (HBsAg) are associated with increased risks of liver cancer, according to a study published online Oct. 24 in the Journal of Gastroenterology and Hepatology.

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