Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer- testis antigens and is common in various types of cancers.
in this study, for the first time, we performed immunohistochemical analysis to evaluate the expression of MAGE-A3 in 153 prostate tissue samples including prostate cancer (PCa), benign prostatic hyperplasia (BPH) and high-grade prostatic intraepithelial neoplasia (HPIN).
Increased Both nuclear and cytoplasmic expression of MAGE-A3 was significantly found in PCa tissues compared to both HPIN and BPH tissues (nuclear expression at P=0.011, and cytoplasmic expression at p=0.034; for both comparisons P<0.0001, respectively). A significant correlation was observed between higher nuclear and cytoplasmic expressions of MAGE-A3 with Gleason score (P 7) were independent predictors of the DFS (both; P=0.019). Nuclear expression of MAGE-A3 was also significantly related to BCR-FS (P=0.015).
MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa.

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