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October 2017 Briefing – Pathology

October 2017 Briefing – Pathology
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Here are what the editors at HealthDay consider to be the most important developments in Pathology for October 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Depressive Symptoms Increase During Internship Year

TUESDAY, Oct. 31, 2017 (HealthDay News) — Depressive symptoms increase during the internship year for training physicians, with a greater increase among women, according to a study published online Oct. 30 in JAMA Internal Medicine.

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Children of Immigrants Less Likely to be Up-to-Date on Shots

TUEDAY, Oct. 31, 2017 (HealthDay News) — Children up to age 36 months with at least one foreign-born parent are less likely to be up-to-date on recommended vaccinations, according to a study published online Oct. 26 in Morbidity and Mortality Weekly Report.

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Computed Tomography Features Vary Based on BRCA Status

THURSDAY, Oct. 31, 2017 (HealthDay News) — Qualitative computed tomography (CT) features differ between patients with BRCA-mutant high-grade serous ovarian cancer (HGSOC) and patients with BRCA wild-type HGSOC, according to a study published in the November issue of Radiology.

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Ohio Upholds Law Requiring HIV-Infected to Tell Sex Partners

TUESDAY, Oct. 31, 2017 (HealthDay News) — The Ohio Supreme Court has unanimously upheld the constitutionality of a law requiring HIV-infected individuals to tell their sexual partners of their status before having sex, according to a report published by the Associated Press.

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Retinal Sensitivity Linked to Cognitive Status in T2DM

TUESDAY, Oct. 31, 2017 (HealthDay News) — In patients with type 2 diabetes, retinal sensitivity is associated with cognitive status, according to a study published in the September issue of Diabetes.

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PFA-100-Measured Aspirin Resistance Linked to CV Events

TUESDAY, Oct. 31, 2017 (HealthDay News) — Aspirin resistance, measured using the Platelet Function Analyzer (PFA)-100 system, is associated with cardiovascular events in aspirin-treated patients, according to a study published online Oct. 21 in the Journal of Clinical Pharmacy and Therapeutics.

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Internists Key to Identifying Need for Genetic Counseling for Cancer

TUESDAY, Oct. 31, 2017 (HealthDay News) — Internists play an important role in identifying which patients may be predisposed to cancer and could benefit from genetic counseling, according to an opinion piece published online Oct. 30 in the Annals of Internal Medicine.

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Ultrasonography Not Necessary for Evaluation of Hypothyroidism

TUESDAY, Oct. 31, 2017 (HealthDay News) — Imaging studies, including thyroid ultrasonography, are not required for the evaluation of hypothyroidism, and their risks include treatment of incidentally discovered nodules, patient and physician anxiety, and significant cost, according to a clinical review article published online Oct. 30 in JAMA Internal Medicine.

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Diabetes of Exocrine Pancreas Often Classified as T2DM

MONDAY, Oct. 30, 2017 (HealthDay News) — Diabetes that follows pancreatic disease is frequently classified as type 2 diabetes but is associated with worse glycemic control and higher use of insulin within five years than type 2 diabetes, according to a study published in the August issue of Diabetes Care.

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Fish Can Trigger Food Protein-Induced Enterocolitis Syndrome

MONDAY, Oct. 30, 2017 (HealthDay News) — Fish is an important trigger of food protein-induced enterocolitis syndrome (FPIES), according to a study published online Oct. 20 in Allergy.

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Multimodal Surveillance Regimen May Not Benefit BRCA Carriers

MONDAY, Oct. 30, 2017 (HealthDay News) — Automated breast ultrasonography may not be of added value to yearly full-field digital (FFD) mammography and dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging surveillance of carriers of the BRCA mutation, according to a study published in the November issue of Radiology.

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Kidney Damage Seen in Most Patients With Long-Lasting T1D

MONDAY, Oct. 30, 2017 (HealthDay News) — Most patients with type 1 diabetes (T1D) of long duration have some degree of kidney disease, according to a study published online Oct. 4 in Diabetes Care.

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Flow Cytometry Assesses Minimal Residual Disease in Myeloma

MONDAY, Oct. 30, 2017 (HealthDay News) — Data on methods used for assessing minimal residual disease (MRD) in multiple myeloma (MM) are presented in a report published online Oct. 23 in the International Journal of Laboratory Hematology.

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Elastography and Color Doppler Improve Breast Ultrasound

MONDAY, Oct. 30, 2017 (HealthDay News) — The combination of elastography and color Doppler ultrasonography (US) with B-mode US in women with dense breasts can increase the positive predictive value of screening and reduce the number of false-positives, according to a study published in the November issue of Radiology.

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AAP Releases Policy Statement on Cord Blood Banking

MONDAY, Oct. 30, 2017 (HealthDay News) — The American Academy of Pediatrics (AAP) has released new information to guide pediatricians, obstetricians, and other health care providers in responding to parents’ questions about cord blood donation and banking, according to a policy statement published online Oct. 30 in Pediatrics.

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E-Cigarettes Alter Defense Proteins in Airway Secretions

MONDAY, Oct. 30, 2017 (HealthDay News) — E-cigarette use changes the profile of innate defense proteins in airway secretions, according to a study published online Oct. 20 in the American Journal of Respiratory and Critical Care Medicine.

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Maternal Use of Acetaminophen Linked to ADHD in Offspring

MONDAY, Oct. 30, 2017 (HealthDay News) — Maternal use of acetaminophen in pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD) in offspring, according to a study published online Oct. 30 in Pediatrics.

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Treatment for Stage I NSCLC Patients Up From 2000 to 2010

FRIDAY, Oct. 27, 2017 (HealthDay News) — For patients with stage I non-small-cell lung cancer (NSCLC), the odds of receiving radiation therapy (RT) or surgery increased from 2000 to 2010, with improved survival during the same period, according to a study published online Oct. 26 in the Annals of Thoracic Surgery.

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Incretin Tied to Better Outcomes in NOCS-Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) — Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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70-Gene Signature Impacts Treatment Decisions in Breast CA

FRIDAY, Oct. 27, 2017 (HealthDay News) — The 70-gene signature (GS) assay affects treatment decisions among physicians treating patients identified as being at intermediate risk with the 21-gene assay (21-GA), according to a study published online Oct. 26 in JAMA Oncology.

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Gastric Cancer Incidence Down, Survival Up

FRIDAY, Oct. 27, 2017 (HealthDay News) — Since 1984, there has been decreased incidence and increased survival rates for gastric cancer (GC), but long-term survival remains low, according to a study published online Oct. 19 in the Journal of Gastroenterology and Hepatology.

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Arterial Stiffness Linked to Incidence of Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) — Increased arterial stiffness, as measured by carotid-femoral pulse wave velocity (c-f PWV), is associated with increased incidence of diabetes, according to a study published online Sept. 29 in Diabetes Care.

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HER3 Linked to Improved Survival With Panitumumab

THURSDAY, Oct. 26, 2017 (HealthDay News) — Higher HER3 expression is associated with improved survival with the addition of panitumumab treatment for patients with RAS wild-type (wt) advanced colorectal cancer, according to a study published online Oct. 26 in JAMA Oncology.

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Concerns Surround Use of Direct-to-Consumer Genetic Testing

THURSDAY, Oct. 26, 2017 (HealthDay News) — Direct-to-consumer genetic testing raises unique concerns and considerations, according to a committee opinion published online Oct. 24 in Obstetrics & Gynecology.

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Locus ID’d That Links Comorbid Alcohol Dependence, Depression

THURSDAY, Oct. 26, 2017 (HealthDay News) — A newly identified genetic risk variant is associated with comorbid alcohol dependence (AD) and major depression (MD) in African Americans, according to a study published online Oct. 25 in JAMA Psychiatry.

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Gifts From Pharma Companies Influence Prescribing Behavior

THURSDAY, Oct. 26, 2017 (HealthDay News) — Receipt of gifts from pharmaceutical companies is associated with more prescriptions per patient and more costly prescriptions, according to a study published online Oct. 25 in PLOS One.

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Borderline Pulmonary HTN Linked to Increased Mortality Risk

THURSDAY, Oct. 26, 2017 (HealthDay News) — For patients undergoing right heart catheterization (RHC), borderline pulmonary hypertension (PH) is associated with increased risk of mortality, according to a study published online Oct. 25 in JAMA Cardiology.

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HIV Drug Resistance Is Threatening Gains of Treatment

THURSDAY, Oct. 26, 2017 (HealthDay News) — Resistance to antiretroviral therapy (ART) is threatening the recent gains of treatment in the rate of new HIV infections, according to a perspective article published online Oct. 25 in the New England Journal of Medicine.

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Surgery Reduces Seizures in Drug-Resistant Epilepsy

THURSDAY, Oct. 26, 2017 (HealthDay News) — For pediatric patients with drug-resistant epilepsy, surgery can improve freedom from seizures, and among adults with drug-resistant focal epilepsy undergoing surgery, hippocampal sclerosis is the most common histopathological diagnosis, according to two studies published online Oct. 25 in the New England Journal of Medicine.

Abstract/Full Text (subscription or payment may be required) — Dwivedi
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Vitamin D Supplements Improve Markers of Bone Turnover in CKD

WEDNESDAY, Oct. 25, 2017 (HealthDay News) — For patients with chronic kidney disease (CKD), cholecalciferol supplementation can correct vitamin D deficiency and improve markers of bone turnover, according to a study published online Oct. 17 in the Journal of Bone and Mineral Research.

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Diabetes Tied to Worse Outcomes in Heart Failure Patients

WEDNESDAY, Oct. 25, 2017 (HealthDay News) — Among patients with acute heart failure (HF), long-term prognosis is worse in those who have diabetes than in those who do not, though prognosis has improved in both groups, according to a study published online Oct. 5 in Diabetes Care.

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Undiagnosed Diabetes Accounts for Small Portion of Diabetes

WEDNESDAY, Oct. 25, 2017 (HealthDay News) — Undiagnosed diabetes accounts for a relatively small proportion of the total diabetes population in the United States, according to a study published online Oct. 23 in the Annals of Internal Medicine.

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Alterations in Gut Microbiome Noted Within 72 Hours of Injury

WEDNESDAY, Oct. 25, 2017 (HealthDay News) — Critically injured patients develop changes in the composition of the gut microbiome within 72 hours, according to a study published online Oct. 23 in Trauma Surgery & Acute Care Open.

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Researchers Study Mediating Role of Leptin in Bulimia

WEDNESDAY, Oct. 25, 2017 (HealthDay News) — Leptin appears to mediate the correlation between weight suppression (WS) and duration of illness in bulimia nervosa-syndrome (BN-S), according to a study published online Oct. 16 in the International Journal of Eating Disorders.

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AMA Addresses Physicians’ Role in Addressing Unsafe Water

TUESDAY, Oct. 24, 2017 (HealthDay News) — Clinicians should be trained to recognize symptoms of contaminated water use in order to help prevent contamination and execute other public health duties, according to an American Medical Association (AMA) report about the October issue of the AMA Journal of Ethics.

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Inverse Association Seen for Coffee Drinking, Markers of CVD

TUESDAY, Oct. 24, 2017 (HealthDay News) — There appears to be an inverse association between coffee intake and protein markers linked to cardiovascular disease, according to a study published online Oct. 16 in the Journal of Internal Medicine.

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Statins May Raise Odds of T2DM in Those at High Risk

TUESDAY, Oct. 24, 2017 (HealthDay News) — For populations at high-risk for diabetes, statin use is associated with increased risk of developing diabetes, according to a study published online Oct. 23 in BMJ Open Diabetes Research & Care.

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Design Thinking Enables Med Students to Solve Challenges

MONDAY, Oct. 23, 2017 (HealthDay News) — A joint effort between students at Warren Alpert Medical School of Brown University and Rhode Island School of Design (RISD) is training future physicians in design thinking to help identify and repair health system issues that contribute to physician burnout, according to an article by the American Medical Association.

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Sudden Death Most Common CV Death in T2DM/ASCVD

MONDAY, Oct. 23, 2017 (HealthDay News) — Among patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD), sudden death is the most common category of cardiovascular (CV) mortality, according to a study published online Oct. 6 in Diabetes Care.

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Smoking Alters Genetic Relationship with Parkinson’s

MONDAY, Oct. 23, 2017 (HealthDay News) — Smoking may modify a previously reported genetic association with Parkinson’s disease (PD), according to an analysis published online Oct. 5 in the Annals of Neurology.

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2003 to 2014 Saw Drop in Urinary Arsenic in Public Water Users

MONDAY, Oct. 23, 2017 (HealthDay News) — From 2003 to 2014, urinary arsenic decreased among users of public water systems but not among private well users, according to a study published online Oct. 22 in the The Lancet Public Health.

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Leukemia Patients Who Survive Severe GVHD Often Fare Worse

MONDAY, Oct. 23, 2017 (HealthDay News) — After hematopoietic stem cell transplantation (HSCT) for acute leukemia, patients who survive severe acute graft-versus-host disease (aGVHD) have a higher risk of developing extensive chronic GVHD (cGVHD) and a higher rate of non-relapse mortality compared with those who did not develop severe aGVHD, according to a study published online Oct. 13 in the Journal of Internal Medicine.

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Herbal and Dietary Supplements Are Commonly Mislabeled

FRIDAY, Oct. 20, 2017 (HealthDay News) — Mislabeling of herbal and dietary supplements (HDS) is common, occurring in more than half of products tested, according to a study scheduled for presentation at The Liver Meeting, being held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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Alcoholic Cirrhosis Linked to Increased Admissions, Costs

FRIDAY, Oct. 20, 2017 (HealthDay News) — Compared with patients who have non-alcoholic cirrhosis, those with alcoholic cirrhosis are sicker at presentation, have more admissions and readmissions, and have nearly double the health care costs, according to a study scheduled for presentation at The Liver Meeting, being held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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Clinician Job Satisfaction Linked to Improved Burnout Scores

FRIDAY, Oct. 20, 2017 (HealthDay News) — Clinicians’ job satisfaction is associated with improved burnout scores and reduced intention to leave their practices, according to a study published in the October issue of Health Affairs.

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H7N9 Avian Influenza May Be Capable of Pandemic

FRIDAY, Oct. 20, 2017 (HealthDay News) — A highly pathogenic H7N9 avian influenza variant has evolved and now has the potential to cause a pandemic, according to a study published online Oct. 19 in Cell Host & Microbe.

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For Hepatitis B Patients, Aspirin Tied to Lower Risk of HCC

FRIDAY, Oct. 20, 2017 (HealthDay News) — Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma (HCC), according to a study scheduled for presentation at The Liver Meeting, held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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In Norway, Risk of SCC After Organ Transplant Has Fallen

FRIDAY, Oct. 20, 2017 (HealthDay News) — For organ recipients in Norway, the risk of skin cancer, particularly squamous cell carcinoma (SCC), has decreased since the mid-1980s, according to a study published online Oct. 18 in JAMA Dermatology.

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Melanoma Staging Undergoes Evidence-Based Revision

FRIDAY, Oct. 20, 2017 (HealthDay News) — The American Joint Committee on Cancer (AJCC) melanoma staging system has been revised, according to a report published online Oct. 13 in CA: A Cancer Journal for Clinicians.

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Oncogenic Oral HPV DNA Detected in 3.5 Percent of Adults

FRIDAY, Oct. 20, 2017 (HealthDay News) — Men have a higher prevalence of oncogenic oral human papillomavirus (HPV) than women, and prevalence increases with the number of lifetime oral sexual partners and tobacco use, according to a study published online Oct. 19 in the Annals of Oncology.

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High Percentage of HIV-Diagnosed Women Not in Care

FRIDAY, Oct. 20, 2017 (HealthDay News) — A high percentage of women receiving a new HIV diagnosis have already received this diagnosis in the past but are not undergoing HIV medical care, according to a study published online Oct. 19 in Morbidity and Mortality Weekly Report.

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CDC Updates Zika Guidance for Infant Care

FRIDAY, Oct. 20, 2017 (HealthDay News) — The U.S. Centers for Disease Control and Prevention (CDC) has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection, according to a report published online Oct. 19 in Morbidity and Mortality Weekly Report.

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Conditions Tied to Clinician Dissatisfaction Are Modifiable

THURSDAY, Oct. 19, 2017 (HealthDay News) — Modifiable conditions, like chaos, incohesiveness, and lack of communication, contribute to unsatisfying workplaces for clinicians, according to a study published in the October issue of Health Affairs.

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Uninsurance Down by One-Third for Cancer Diagnoses in 2014

THURSDAY, Oct. 19, 2017 (HealthDay News) — In the first year of the Affordable Care Act (ACA), there was a relative decrease of one-third in uninsurance among adults with new cancer diagnoses, according to a research letter published online Oct. 19 in JAMA Oncology.

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Gene Expression Assay Classifies Diffuse Large B-Cell Lymphoma

THURSDAY, Oct. 19, 2017 (HealthDay News) — A novel gene expression profiling diffuse large B-cell lymphoma (DLBCL) classifier, which evaluates the expression of 21 markers, is effective for classifying samples, according to a study published online Oct. 17 in the Journal of Molecular Diagnostics.

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Key Stakeholders Discuss How to Make EHRs More Usable

THURSDAY, Oct. 19, 2017 (HealthDay News) — Key stakeholders and physicians discussed electronic health record (EHR) usability and optimization in the American Medical Association Running Your Practice Community.

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MicroRNA-708 Overexpression Suppresses β-Cell Proliferation

THURSDAY, Oct. 19, 2017 (HealthDay News) — Researchers have identified a novel mechanism of glucose regulation of β-cell function and growth by repressing stress-induced microRNA-708 (miR-708), according to a study published online Oct. 2 in Diabetes.

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Sharing Passwords Is Widespread Among Medical Staff

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — Sharing of passwords to access electronic medical records is common among medical staff members, according to a study published in the July issue of Healthcare Informatics Research.

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PPI Use Linked to Increased Risk of Ischemic Stroke, MI

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — Proton pump inhibitor (PPI) use is associated with increased risk of first-time ischemic stroke and myocardial infarction (MI), according to a study published online Oct. 12 in the Journal of Internal Medicine.

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No Increased Risks for DOAC Use Versus Warfarin in VTE

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — For patients with venous thromboembolism, direct oral anticoagulant (DOAC) use is not associated with increased risk of major bleeding or mortality within the first 90 days compared with warfarin use, according to a study published online Oct. 17 in the BMJ.

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Visceral Adipose Tissue Index IDs Risk of HCC in Cirrhosis

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — For male patients with cirrhosis, visceral adipose tissue index (VATI) is an independent risk factor for hepatocellular carcinoma (HCC), according to a study published online Oct. 10 in Hepatology.

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Tau May Predict Neurological Outcome After Cardiac Arrest

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — Serum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest, according to a study published online Oct. 5 in the Annals of Neurology.

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Overall Survival Up for Melanoma Brain Metastases

WEDNESDAY, Oct. 18, 2017 (HealthDay News) — Overall survival (OS) for patients with melanoma brain metastases (MBM) has improved significantly since 2000, according to a study published online Oct. 12 in Cancer.

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Machine Learning Model Predicts Risk of Upgrade to Breast CA

TUESDAY, Oct. 17, 2017 (HealthDay News) — A machine learning model can predict the risk of upgrade of high-risk breast lesions (HRLs) to cancer, according to a study published online Oct. 17 in Radiology.

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Mortality Up for Male Recipients of Blood From Ever-Pregnant

TUESDAY, Oct. 17, 2017 (HealthDay News) — For males, receipt of a red blood cell transfusion from an ever-pregnant female is associated with increased rate of all-cause mortality compared with a male donor, according to a study published online Oct. 17 in the Journal of the American Medical Association.

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Prevalence of Oral HPV Infection Higher for U.S. Men

TUESDAY, Oct. 17, 2017 (HealthDay News) — Oral human papillomavirus (HPV) infection and high-risk oral HPV infection are more common among men than women, according to a study published online Oct. 16 in the Annals of Internal Medicine.

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‘Liquid Biopsy’ Shows Promise for Hepatocellular Carcinoma

TUESDAY, Oct. 17, 2017 (HealthDay News) — ‘Liquid biopsy’ technology holds promise for diagnosing, monitoring, and predicting prognosis in patients with hepatocellular carcinoma (HCC), according to a study published online Oct. 9 in Nature Materials.

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Gastric Acid Suppression May Promote Liver Injury

TUESDAY, Oct. 17, 2017 (HealthDay News) — Based on data from mouse models and humans, a decrease in gastric acid secretion due to use of gastric acid suppressive medications seems to promote overgrowth of intestinal Enterococcus, which promotes liver disease, according to a study published online Oct. 10 in Nature Communications.

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Female Physicians May Be Especially at Risk of Burnout

TUESDAY, Oct. 17, 2017 (HealthDay News) — Female physicians are more burned out than their male colleagues, but there are steps they can take to reduce the stress associated with burnout, according to a blog post published in Medical Economics.

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Ketamine Not Linked to PTSD in Military Trauma Setting

TUESDAY, Oct. 17, 2017 (HealthDay News) — Ketamine administration is not associated with post-traumatic stress disorder (PTSD) in the military trauma setting, according to a study published online Oct. 3 in Anaesthesia.

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Most Female Physicians Have Faced Sexist Patient Comments

MONDAY, Oct. 16, 2017 (HealthDay News) — Most female physicians have been sexually harassed by patients at some point in their careers, according to a blog post published in Medical Economics.

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Moderate Alcohol Consumption Tied to Lower Heart Failure Risk

MONDAY, Oct. 16, 2017 (HealthDay News) — Moderate alcohol consumption is associated with reduced risk of heart failure but not atrial fibrillation (AF), according to a study published online Oct. 11 in JACC: Heart Failure.

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Worse HIV Care Outcomes for Hispanics, Latinos

MONDAY, Oct. 16, 2017 (HealthDay News) — HIV care outcomes are worse for Hispanics and Latinos, especially for injection drug users, according to a study published online Oct. 12 in Morbidity and Mortality Weekly Report.

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Model Predicts Cost-Effectiveness for Anal Lesion Treatment

MONDAY, Oct. 16, 2017 (HealthDay News) — Cost-effective management of precancerous anal intraepithelial lesions in HIV-positive men who have sex with men (MSM) varies by age, according to a study published online Sept. 26 in Cancer.

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Aqueous Humor Can Serve as Surrogate Tumor Biopsy

FRIDAY, Oct. 13, 2017 (HealthDay News) — A novel method will allow for analyses of tumor-derived DNA in eyes with retinoblastoma (Rb) undergoing salvage therapy that have not been enucleated, according to a study published online Oct. 12 in JAMA Ophthalmology.

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Quality Issues for Both Paper-, Electronic-Based Health Records

FRIDAY, Oct. 13, 2017 (HealthDay News) — Both paper-based and electronic health records (EHRs) have shortcomings in terms of quality of content, process, and structure, with poor quality of nursing documentation seen for both methods, according to a study published online Oct. 5 in the Journal of Clinical Nursing.

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Liraglutide Not Tied to Higher Risk of Cardiovascular Events

FRIDAY, Oct. 13, 2017 (HealthDay News) — Liraglutide treatment for weight management is not associated with increased risk of cardiovascular events, according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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U.S. Filipinos Have Higher Thyroid Cancer Mortality

FRIDAY, Oct. 13, 2017 (HealthDay News) — Filipinos die of thyroid cancer at higher rates than non-Filipino Asian (NFA) and non-Hispanic white (NHW) individuals of similar ages, according to a study published online Sept. 7 in Cancer.

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Genetic Variant Tied to Prostate Cancer Outcomes

THURSDAY, Oct. 12, 2017 (HealthDay News) — The HSD3B1 (1245C) allele is associated with more rapid development of metastases in men with biochemically recurrent prostate cancer, and it predicts response to nonsteroidal CYP17A1 inhibition, according to two studies published online Oct. 12 in JAMA Oncology.

Abstract/Full Text (subscription or payment may be required) — Hearn
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Court Considering Fate of Noneconomic Damages Cap

THURSDAY, Oct. 12, 2017 (HealthDay News) — The Wisconsin Supreme Court is considering whether it will hear a case that will determine the fate of the state’s $750,000 cap on noneconomic damages, according to an article published by the American Medical Association (AMA).

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Vaccines Elicit Lasting Immune Response Against Ebola

THURSDAY, Oct. 12, 2017 (HealthDay News) — Two vaccines to prevent Ebola virus disease (EVD) demonstrated immune responses at one month that were largely maintained through 12 months, according to a study published online Oct. 11 in the New England Journal of Medicine.

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New System Streamlines CME Credit Approval Process

THURSDAY, Oct. 12, 2017 (HealthDay News) — The American Academy of Family Physicians (AAFP) and the American Board of Family Medicine (ABFM) have launched a new performance improvement activity credit reporting process called the AAFP Credit System, according to an article published by the AAFP.

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Risk Conferred by T2D Modified by HbA1c in Heart Failure

THURSDAY, Oct. 12, 2017 (HealthDay News) — For patients with heart failure, the risks conferred by type 2 diabetes (T2D) can be stratified by glycemic control and drug treatments, according to a study published online Oct. 11 in JACC: Heart Failure.

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Low-Cost Services a Major Player in Unnecessary Health Spending

THURSDAY, Oct. 12, 2017 (HealthDay News) — The costs associated with low-cost, low-value health services are nearly twice as high as those of high-cost, low-value services, according to a study published in the October issue of Health Affairs.

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2004 to 2014 Saw Increases in Risk Factors in Ischemic Stroke

THURSDAY, Oct. 12, 2017 (HealthDay News) — From 2004 to 2014 there were increases in the prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in acute ischemic stroke (AIS), according to a study published online Oct. 11 in Neurology.

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Primary, Pulmonary Providers Endorse Lung CA Screening

THURSDAY, Oct. 12, 2017 (HealthDay News) — Primary care clinicians and pulmonologists endorse lung cancer screening (LCS), but there are limitations in their knowledge of screening components, according to a study published online Sept. 21 in the Annals of the American Thoracic Society.

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Medical License Questions Sway Doctors’ Mental Health Help

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — Medical licensure application questions (MLAQs) regarding mental health contribute to physicians’ reluctance to seek help for mental health, according to a study published in the October issue of Mayo Clinic Proceedings.

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Physician Salaries Appear to Be Flat or Declining

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — Anecdotally, physician career coaches report that physician salaries are flat at best, according to an article published in Medical Economics.

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New Tool IDs Mortality Risk After Bladder Cancer Surgery

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — A new risk-stratification tool is able to estimate mortality in patients with urothelial carcinoma of the bladder (UCB) after cystectomy, according to a study published online Sept. 7 in Cancer.

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Statins Tied to Lower Community-Acquired Staph Infection Risk

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — Statin use is associated with a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB), particularly in long-term users, according to a study published in the October issue of Mayo Clinic Proceedings.

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HPV Vaccination After Lesion Treatment Is Likely Cost-Effective

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — For HIV-infected men who have sex with men (MSM), adjuvant quadrivalent human papillomavirus vaccination (qHPV) after treatment of high-grade squamous intraepithelial lesions (HSIL) is likely to be cost-effective, according to a study published online Sept. 12 in Vaccine.

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AAP Releases List of Often-Unnecessary Tests

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — As part of the Choosing Wisely campaign, the American Academy of Pediatrics (AAP) has released a new list of five tests and procedures commonly ordered for signs of early puberty, short height, and other endocrine-related disorders that parents and physicians should question.

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Rising BMI Trends for Children Have Plateaued in Many Countries

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — Rising trends in body mass index (BMI) for children and adolescents have plateaued in many high-income countries after rising for decades but have accelerated in some parts of Asia, according to a study published online Oct. 10 in The Lancet.

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No Causal Link Between Plasma Lipids, Diabetic Retinopathy

WEDNESDAY, Oct. 11, 2017 (HealthDay News) — There does not seem to be a causal relationship between plasma lipids and diabetic retinopathy (DR), according to a study published in the September issue of Diabetes.

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Guide Offers Doctors Tips for Choosing a Health System

TUESDAY, Oct. 10, 2017 (HealthDay News) — A guide has been developed to assist physicians considering joining a physician-led integrated health system, according to a report published by the American Medical Association (AMA).

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Autoimmunities for T1D, Celiac Co-Occur More Than Expected

TUESDAY, Oct. 10, 2017 (HealthDay News) — Co-occurrence of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities significantly exceeds the expected rate, according to a study published online Oct. 10 in Pediatrics.

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Biomarkers of Ovarian Reserve Don’t Indicate Infertility

TUESDAY, Oct. 10, 2017 (HealthDay News) — Biomarkers indicating diminished ovarian reserve versus normal ovarian reserve are not associated with reduced fertility among women aged 30 to 44 years without a history of infertility who have been trying to conceive for three months or less, according to a study published online Oct. 10 in the Journal of the American Medical Association.

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Specific Phenotype Relevant in Subclinical Primary Aldosteronism

TUESDAY, Oct. 10, 2017 (HealthDay News) — A suppressed renin phenotype is associated with higher incidence of incident hypertension than other plasma renin activity (PRA) phenotypes, according to a study published online Oct. 9 in the Annals of Internal Medicine.

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Higher Levels of Fungus ID’d in Patients With Crohn’s

TUESDAY, Oct. 10, 2017 (HealthDay News) — Higher levels of Candida tropicalis, as well as Escherichia coli and Serratia marcescens, are seen in patients with Crohn’s disease, indicating a role for the mycobiome in inflammatory bowel disease (IBD), according to a study published online Oct. 4 in Digestive and Liver Disease.

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Dietary Fat, Relapse Linked in Pediatric Multiple Sclerosis

TUESDAY, Oct. 10, 2017 (HealthDay News) — For children with multiple sclerosis, increased fat intake is associated with an increased risk of relapse, while vegetable intake may be protective, according to a study published online Oct. 9 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Novel Metrics Suggested for Assessing EHR Use

TUESDAY, Oct. 10, 2017 (HealthDay News) — Novel metrics have been developed to assess electronic health record (EHR) use and are described in an opinion article published online Oct. 9 in the Annals of Internal Medicine.

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Patient, Provider Interventions May Up Colonoscopy Rates

TUESDAY, Oct. 10, 2017 (HealthDay News) — For asymptomatic adults with positive fecal blood test results, patient navigators and provider reminders or performance data may help improve colonoscopy rates; however, current evidence about useful system-level interventions is insufficient, according to a review published online Oct. 9 in the Annals of Internal Medicine.

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Adding Albumin to Risk Score Improves Mortality Prediction

MONDAY, Oct. 9, 2017 (HealthDay News) — Serum albumin, as a marker of frailty, can significantly improve the ability of the Society of Thoracic Surgeons (STS) and European System for Cardiac Operative Risk Evaluation (EuroSCORE-2) scores to predict transcatheter aortic valve replacement (TAVR)-related mortality, according to a study published online Sept. 23 in the Journal of the American Geriatrics Society.

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Antibiotic Use Not Linked to Islet, Celiac Disease Autoimmunity

MONDAY, Oct. 9, 2017 (HealthDay News) — Use of antibiotics in early life is not associated with islet or celiac disease (CD) autoimmunity in children at risk for type 1 diabetes (T1D) or CD, according to a study published online Oct. 9 in JAMA Pediatrics.

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Injured Patients Want More Info on Safety Improvement Efforts

MONDAY, Oct. 9, 2017 (HealthDay News) — Communication-and-resolution program (CRP) experiences are positive overall for a small majority of patients and families, but they report that hospitals rarely share information about preventing recurrences, according to a study published online Oct. 9 in JAMA Internal Medicine.

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2016 Physician Quality Reporting System Reports Available

MONDAY, Oct. 9, 2017 (HealthDay News) — The 2016 Physician Quality Reporting System (PQRS) and the 2016 annual Quality and Resource Use reports have been released for individuals and group practices, according to a report published by the American Academy of Family Physicians.

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Negative Margins, Lymph Node Yields Predict Survival

MONDAY, Oct. 9, 2017 (HealthDay News) — Patients treated at hospitals that attain a high rate of negative margins and lymph node yields (LNY) of at least 18 have improved survival after surgery for head and neck squamous cell carcinomas (HNSCC), according to a study published online Oct. 5 in JAMA Otolaryngology — Head & Neck Surgery.

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Human Adenovirus Surveillance Data IDs Type Patterns

MONDAY, Oct. 9, 2017 (HealthDay News) — Human adenovirus (HAdV) surveillance data can be used to determine patterns of circulation for individual HAdV types in the United States and to help with the recognition of outbreaks, according to a study published online Oct. 5 in Morbidity and Mortality Weekly Report.

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Rate of Adverse Effects for Dapagliflozin Similar to Placebo

MONDAY, Oct. 9, 2017 (HealthDay News) — The overall incidence of adverse effects (AEs) and serious AEs (SAEs) is similar in patients with type 2 diabetes mellitus taking dapagliflozin or placebo, according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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Antisocial Behavior May Be Highly Polygenic

MONDAY, Oct. 9, 2017 (HealthDay News) — Antisocial behavior (ASB) may be highly polygenic, with sex-discordant associations identified for some loci, according to a study published online Oct. 4 in JAMA Psychiatry.

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First Test to Detect Zika in Blood Donations Approved

FRIDAY, Oct. 6, 2017 (HealthDay News) — The cobas Zika test has been approved by the U.S. Food and Drug Administration — the first approved screening test to detect the Zika virus in blood donations.

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Short-Lived Benefits for Abusive Supervisory Behavior

FRIDAY, Oct. 6, 2017 (HealthDay News) — Engaging in abusive supervisory behavior may be associated with short-term beneficial effects, but over longer periods of time, abusive supervisory behavior is negatively related to supervisors’ recovery level and engagement, according to a study published online Sept. 11 in the Academy of Management Journal.

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Electrolyte Issues With Chronic Alcohol Use Span Social Spectrum

FRIDAY, Oct. 6, 2017 (HealthDay News) — Electrolyte disturbances and acid-base disorders are common occurrences in patients with chronic alcohol-use disorder regardless of social circumstances, according to a review published online Oct. 4 in the New England Journal of Medicine.

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Stronger Nocebo Effect When Inert Rx Labeled As Expensive

FRIDAY, Oct. 6, 2017 (HealthDay News) — Nocebo hyperalgesia is stronger when an inert treatment is labeled as being an expensive medication rather than a cheap one, according to a study published online Oct. 5 in Science.

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Liver Cancer Remains a Major Public Health Burden Globally

FRIDAY, Oct. 6, 2017 (HealthDay News) — Causes of primary liver cancer differ widely among populations globally, but most cases can be prevented, according to a study published online Oct. 5 in JAMA Oncology.

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Most Cancer Drugs Approved in Europe Show No Survival Benefit

FRIDAY, Oct. 6, 2017 (HealthDay News) — Most cancer drugs that enter the market in Europe have no evidence of benefit for survival or quality of life, according to a study published online Oct. 4 in BMJ.

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21 Percent of Americans Report Experiencing a Medical Error

THURSDAY, Oct. 5, 2017 (HealthDay News) — More than one in five patients report having experienced a medical error, according to a survey released Sept. 28 by the Institute for Healthcare Improvement (IHI)/National Patient Safety Foundation Lucian Leape Institute and NORC at the University of Chicago.

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Stem Cell Gene Therapy Safe for Adrenoleukodystrophy

THURSDAY, Oct. 5, 2017 (HealthDay News) — Early results suggest that stem cell gene therapy is a safe and effective treatment for boys with early-stage cerebral adrenoleukodystrophy, according to a study published online Oct. 4 in the New England Journal of Medicine to coincide with the 2017 Child Neurology Society Annual Meeting, being held Oct. 4 to 7 in Kansas City.

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Reasons Physicians Are Delaying Retirement Vary

THURSDAY, Oct. 5, 2017 (HealthDay News) — Physicians are delaying retirement, often because they feel they are providing a useful service to patients or because of concerns about social interaction in retirement, according to an article published online Sept. 25 in Medical Economics.

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Maternal Multivitamin Use Tied to Lower Risk of Child ASD

THURSDAY, Oct. 5, 2017 (HealthDay News) — Multivitamin supplementation during pregnancy is tied to a reduced risk of autism spectrum disorder (ASD) with intellectual disability, according to a study published online Oct. 4 in BMJ.

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Mid-Adulthood HTN Tied to Higher Dementia Risk in Women

THURSDAY, Oct. 5, 2017 (HealthDay News) — Mid-adulthood hypertension is associated with increased risk of dementia among women but not men, according to a study published online Oct. 4 in Neurology.

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Delivery Characteristics Predict Early-Onset Sepsis Risk

THURSDAY, Oct. 5, 2017 (HealthDay News) — Delivery characteristics of extremely preterm infants can be used to identify those with significantly lower incidence of early-onset sepsis (EOS), according to a study published online Oct. 5 in Pediatrics.

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Pay Inequality, Work-Life Balance Top Concerns for Female Docs

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Many female physicians report feeling disadvantaged when negotiating contracts and feel that they are assessed for promotion using different criteria than those used for men, according to a report published by the American Medical Association (AMA).

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Insurance Type Linked to Surgery Delay in Melanoma

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Patients diagnosed with melanoma are more likely to have treatment delays if they are nonwhite or on Medicaid, while delays are less likely for patients diagnosed or treated by a dermatologist, according to a study published online Oct. 4 in JAMA Dermatology.

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Rate of Obesity-, Overweight-Related Cancers High in the U.S.

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — The burden of overweight- and obesity-related cancer is high in the United States, and incidence has increased in some states and age groups, according to a study published online Oct. 3 in Morbidity and Mortality Weekly Report.

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Commercialization of Generics Impacts Adverse Event Rates

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs, according to a study published online Oct. 3 in Circulation: Cardiovascular Quality and Outcomes.

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Insulinomas May Hold Key to Diabetes Drug Development

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — An analysis of whole-exome and RNA sequencing data reveals mutations, copy number variants, and/or dysregulation of epigenetic modifying genes in insulinomas, which may be candidates for inducing beta cell regeneration, according to a study published online Oct. 3 in Nature Communications.

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Process Promising for On-Site Printing of Custom-Dosed Meds

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Small molecular medicines can be printed precisely using organic vapor jets, according to a study published online Sept. 27 in Nature Communications.

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Scientists Support Genome Editing to Prevent Disease

WEDNESDAY, Oct. 4, 2017 (HealthDay News) — Many basic scientists and clinical researchers support somatic genome editing in adults for prevention of serious disease but not for human enhancement; they also believe the public should be consulted before any clinical application of germline gene editing proceeds, according to survey results published online Oct. 3 in Circulation: Cardiovascular Genetics.

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More U.S. Measles Cases From No Vaccine vs. Imported Disease

TUESDAY, Oct. 3, 2017 (HealthDay News) — While measles incidence is extremely low in the United States, most cases that do occur happen in unvaccinated patients, according to a research letter published online Oct. 3 in the Journal of the American Medical Association.

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Overall Breast Cancer Incidence Up for Some in 2005-2014

TUESDAY, Oct. 3, 2017 (HealthDay News) — Overall breast cancer incidence rates increased among specific racial/ethnic groups from 2005 to 2014, although the overall death rates decreased from 1989 to 2015, according to a study published online Oct. 3 in CA: A Cancer Journal for Clinicians.

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Communication Program Doesn’t Raise Hospital Liability Costs

TUESDAY, Oct. 3, 2017 (HealthDay News) — A communication-and-resolution program, in which hospitals and liability insurers communicate with patients when adverse events occur, does not lead to higher liability costs, according to a study published online Oct. 2 in Health Affairs.

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Fewer Deaths Projected With Switch to Electronic Cigarettes

TUESDAY, Oct. 3, 2017 (HealthDay News) — Replacement of cigarettes with electronic cigarettes (e-cigarettes) is projected to result in fewer premature deaths, even under a pessimistic scenario, according to a study published online Oct. 2 in Tobacco Control.

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Clinical Exome Sequencing Useful for Critically Ill Infants

TUESDAY, Oct. 3, 2017 (HealthDay News) — Clinical exome sequencing is an effective diagnostic tool for infants suspected of having monogenic disorders, according to a study published online Oct. 2 in JAMA Pediatrics.

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Sodium-Glucose Cotransporter 2 Inhibitors Not Cancer Risk Factor

TUESDAY, Oct. 3, 2017 (HealthDay News) — Over the short term there is not a significantly increased overall cancer risk among individuals with type 2 diabetes using sodium-glucose cotransporter 2 (SGLT2) inhibitors, according to a study published in the October issue of Diabetologia.

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Subjective Cognitive Decline Linked to Global Tau Burden

TUESDAY, Oct. 3, 2017 (HealthDay News) — For clinically healthy older adults, subjective cognitive decline (SCD) is associated with increasing entorhinal cortical tau burden and β-amyloid (Aβ) burden, according to a study published online Oct. 2 in JAMA Neurology.

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Hospital Discharges for Prescription Opioids Have Fallen

TUESDAY, Oct. 3, 2017 (HealthDay News) — Prescription opioid-related inpatient and emergency department (ED) discharges have decreased since 2010, while heroin-related discharges have increased sharply since 2008, according to a study published online Oct. 2 in Health Affairs.

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High Epsom Salt Intake Can Lead to Severe Liver Injury

TUESDAY, Oct. 3, 2017 (HealthDay News) — Epsom salt intake can lead to severe liver injury in predisposed patients, according to a case study published online Oct. 2 in BMJ Case Reports.

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Tattoo Pigment Hypersensitivity Can Mimic Lymphoma

TUESDAY, Oct. 3, 2017 (HealthDay News) — Tattoo pigment hypersensitivity causing widespread lymphadenopathy has been described in a case report published online Oct. 2 in the Annals of Internal Medicine.

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Recent Immigrants to Canada More Likely to Die in ICU

MONDAY, Oct. 2, 2017 (HealthDay News) — Recent immigrants to Canada are more likely to receive aggressive care and die in intensive care than long-standing residents, according to a study published online Oct. 2 in the Journal of the American Medical Association.

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Skipping Breakfast Tied to Increased Odds of Atherosclerosis

MONDAY, Oct. 2, 2017 (HealthDay News) — Habitual skipping of breakfast is associated with increased likelihood of atherosclerosis independent of traditional and dietary cardiovascular (CV) risk factors, according to a study published online Oct. 2 in the Journal of the American College of Cardiology.

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Tdap Given in Pregnancy Protects Infants From Pertussis

MONDAY, Oct. 2, 2017 (HealthDay News) — Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination during the third trimester of pregnancy is effective for preventing pertussis in infants in the first months of life, according to a study published online Sept. 28 in Clinical Infectious Diseases.

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Electronic Triage System Risk-Stratifies ER Patients

MONDAY, Oct. 2, 2017 (HealthDay News) — An electronic triage (e-triage) system based on machine learning can predict the likelihood of acute outcomes, enabling improved patient differentiation, according to a study published online Sept. 6 in the Annals of Emergency Medicine.

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High Coffee Intake Tied to Lower Mortality in HIV/HCV

MONDAY, Oct. 2, 2017 (HealthDay News) — Drinking three or more cups of coffee per day halves all-cause mortality risk in patients co-infected with HIV/hepatitis C virus (HCV), according to a study published online Sept. 21 in the Journal of Hepatology.

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Hirsutism Strongly Predicts Metabolic Dysfunction in PCOS

MONDAY, Oct. 2, 2017 (HealthDay News) — There is a strong correlation between hirsutism and metabolic dysfunction in women with polycystic ovary syndrome (PCOS), according to a study published online Sept. 21 in the Journal of Cosmetic Dermatology.

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Hypermutated ctDNA Linked to Checkpoint Inhibitor Response

MONDAY, Oct. 2, 2017 (HealthDay News) — For patients with diverse malignancies, hypermutated blood-derived circulating tumor DNA (ctDNA) is associated with checkpoint inhibitor response, according to a study published online Oct. 2 in Clinical Cancer Research.

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