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Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.

Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.
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Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M,


Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M, (click to view)

Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M,

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Scientific reports 2017 04 137() 46419 doi 10.1038/srep46419
Abstract

Frailty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (<32.5 kg in men, <19.5 kg in women), and short one-leg standing time (<20 seconds). These can be easily measured in the clinician's office when seeing patients. We investigated the possible association between SF score and mild cognitive impairment (MCI) in a cross-sectional study with 838 independent middle-aged to elderly participants (319 men, mean age 65.1years). In total, 118 participants were diagnosed with MCI. A SF score of 2 was significantly associated with the presence of MCI (odds ratio 4.6, 95% confidence interval: 1.9-6.9, p = 0.0001) even after adjustment for age and sex. Stepwise regression analyses showed that a SF score of 2 was associated with the presence of MCI, independently of central pulse pressure and silent cerebral infarcts. These findings indicate that the SF score is a useful frailty parameter to predict MCI in an apparently independent population.

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