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One-hour OGTT plasma glucose at GDM diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance.

One-hour OGTT plasma glucose at GDM diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance.
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Nishikawa T, Ono K, Hashimoto S, Kinoshita H, Watanabe T, Araki H, Otsu K, Sakamoto W, Harada M, Toyonaga T, Kawakami S, Fukuda J, Haga Y, Kukidome D, Takahashi T, Araki E,


Nishikawa T, Ono K, Hashimoto S, Kinoshita H, Watanabe T, Araki H, Otsu K, Sakamoto W, Harada M, Toyonaga T, Kawakami S, Fukuda J, Haga Y, Kukidome D, Takahashi T, Araki E, (click to view)

Nishikawa T, Ono K, Hashimoto S, Kinoshita H, Watanabe T, Araki H, Otsu K, Sakamoto W, Harada M, Toyonaga T, Kawakami S, Fukuda J, Haga Y, Kukidome D, Takahashi T, Araki E,

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Journal of diabetes investigation 2018 04 06() doi 10.1111/jdi.12848
Abstract
AIMS/INTRODUCTION
Because gestational diabetes mellitus (GDM) is a risk for adverse perinatal outcomes, and patients with a history of GDM have an increased risk of impaired glucose tolerance (IGT). Here, we conducted two non-interventional and retrospective studies of GDM patients in Japan.

MATERIALS AND METHODS
In the first study, we enrolled 529 GDM patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum IGT.

RESULTS
In the first study, gestational weeks at GDM diagnosis and history of pregnancy were significantly lower and pregestational BMI, family history of DM, 1- and 2-hour glucose levels in a 75-g OGTT, the number of abnormal values in a 75-g OGTT, and HbA1c were significantly higher in subjects with insulin therapy. In the second study, 1- and 2-hour glucose levels in a 75-g OGTT, the number of abnormal values in a 75-g OGTT, HbA1c, and ketone bodies in a urine test were significantly higher in IGT subjects. Logistic regression analysis showed that gestational weeks at GDM diagnosis, 1-hour glucose levels in a 75-g OGTT, and HbA1c were significant predictors of the need for insulin therapy, and 1-hour glucose levels in a 75-g OGTT at diagnosis and ketone bodies in a urine test were significant predictors for postpartum IGT.

CONCLUSIONS
Antepartum 1-hour glucose levels in a 75-g OGTT was a predictor of the need for insulin therapy in pregnancy and postpartum IGT. This article is protected by copyright. All rights reserved.

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