Aortic valve stenosis, or aortic stenosis (AS), is a condition that occurs when the heart’s aortic valve narrows, resulting in reduced blood flow from the heart to the aorta. The clinical management and outcomes of patients with AS are not well studied. This study aims to evaluate the clinical outcomes of patients with asymptomatic AS.

This registry-based prospective study included a total of 1,375 asymptomatic patients with moderate or severe AS. The primary outcomes of the study were natural history, the need for aortic valve replacement, and survival with moderate-severe AS.

Of 1,375 included patients, 861 (62.6%) had severe AS. During the mean follow-up of 27 months, the mean overall survival was 93% at 2 years, 86% at 4 years, and 75% at 8 years. A total of 105 (7.6%) patients died under observation, 57 (54.8%) of whom died from cardiovascular causes. Further analysis showed that a542 (39.4%) patients underwent aortic valve replacement, including 388 (71.6%) patients with severe AS. The mean 2-year and 4-year AVR-free survival rates for asymptomatic patients with severe AS were 54% and 32%, respectively.

The research concluded that patients with asymptomatic AS were at a lower risk of death, and early intervention can increase the health outcomes in patients.