Advertisement

 

 

Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells.

Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells.
Author Information (click to view)

Fujio K, Yamamoto K, Okamura T,


Fujio K, Yamamoto K, Okamura T, (click to view)

Fujio K, Yamamoto K, Okamura T,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Current topics in microbiology and immunology 2017 09 20() doi 10.1007/82_2017_59

Abstract

Regulatory T cells (Treg cells) play crucial roles in the induction of peripheral tolerance to self- and foreign-antigens. IL-10-producing regulatory T cells (IL-10-producing Treg cells) constitute a Treg cell subset characterized by the production of high amounts of IL-10, cytokine-mediated immunosuppressive capabilities, and independence of Foxp3 expression for their suppressive activity. In the past decade, identifying naturally occurring IL-10-producing Treg cells was difficult due to the lack of suitable surface markers. More recently, lymphocyte activation gene 3 (LAG-3) is a CD4 homologue that has been identified as a marker for IL-10-producing Treg cells. CD4(+)CD25(-)LAG3(+) T cells produce large amounts of IL-10 and suppress colitis in a mouse model. These CD4(+)CD25(-)LAG3(+) Treg cells also exhibit suppressive activity in murine models of lupus and humoral immunity in a TGF-β3-dependent manner. Moreover, the combined expression of LAG-3 and CD49b identifies IL-10-producing Treg cells in mice and humans more specifically. Recently, LAG-3 has gained more attention in the context of immune checkpoints because it believed to be related to T cell tolerance and exhausted T cells that infiltrate the tumor microenvironment. Tumors and the tumor microenvironment promote development of IL-10-producing Treg cells and foster tumor growth. This response might interfere with protective immune responses. Understanding LAG-3-expressing IL-10-producing Treg cells may contribute to the development of novel therapeutic strategies in immune-mediated diseases.

Submit a Comment

Your email address will not be published. Required fields are marked *

3 × 2 =

[ HIDE/SHOW ]