This study states that the coronavirus disease 2019 (COVID-19) pandemic continues to have a devastating impact on all aspects of life, worldwide. It has been challenging. Professionally, all aspects of medical care and research have been altered. At the time of writing this “Special Report,” 141 million individuals have endured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with over 3.01 million succumbing to this tragedy. Children are largely spared from death due to infection, with mortality less than 400 cases in the United States and Canada of over a million cases. However, we now have a different concern. There is a novel postinfectious phenotype described in children that have now been reported in over 3,000 cases in the United States and likely has an impact on children worldwide. This multisystem inflammatory syndrome in children (MIS-C) (1) is not described in other viral infections, and we need more data to accurately assess global epidemiologic impact and burden on children worldwide.

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