For a study, researchers sought to provide knowledge regarding the diagnosis, treatment, and long-term effects of coagulation disorders in juvenile COVID-19 hospitalized patients. There was insufficient evidence for the best prophylactic antithrombotic therapy, and their connection to an elevated risk for thromboembolic events was uncertain. Therefore, a prospective study focused on the coagulation anomalies of patients, the normalization of the coagulation profile with or without anticoagulant prophylaxis, and the clinical outcome of the illness was conducted in all children hospitalized for COVID-19 for 6 months. About 223 patients (middle age: 11.4 months) were signed up for the review. Coagulation anomalies were identified in 92.4% of patients with expanded D-dimer levels, the most well-known irregularity recognized in 84.3% of patients. Prophylactic anticoagulation was started exclusively in 7 (3.1%) chosen patients with serious COVID-19 and no less than 2 gamble factors for venous thromboembolism (VTE) and in all patients with a history of VTE. Follow-up coagulation profile in 85 patients showed that changes after some time had a propensity towards standardization independently of the commencement of anticoagulant thromboprophylaxis. No thrombotic difficulties were noticed 3 months upon release. Even in severe cases, aberrant results in the coagulation profile were not linked to an increased risk of VTE. Regardless of the administration of anticoagulant thromboprophylaxis, a trend toward normalization was seen early in the course of the disease.