Precision medicines could help strengthen asthma diagnosis and care, but special requirements for the implementation of this technique have to be seen in tropics. We discuss recent development in tropical regions of precise allergy, emphasising their constraints and their requirements in highly admixed communities living under conditions where domestic mites and Helminth infections are highly exposed. Advances in the genetics of the great diversity of tropical populations have been made. New reasons for predisposition proposed by genes involved in shared biological processes between nemata immune responses and allergic reacciones. Genome wide-ranging asthma interaction trials gradually concentrate on certain strongly repeated genes, such as those in 17q31-13 chromosome, that have also been replicated in populations of African descent. Certain diagnostic problems are now more obvious as part of phenotype definition due to the endemicity of helminth infections.
The therapeutic implications for asthma in the tropics of developments in accurate medicine are still small and contribute to the determined diagnosis of its components. Further fundamental and clinical investigation is necessary for the identification and precise classification of genetic, epigenetic or other markers that allow the genetic, epigenetic or other biological phenotypes. The selection of customised therapies is greatly improved.
