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Phase changes in neuronal postsynaptic spiking due to short term plasticity.

Phase changes in neuronal postsynaptic spiking due to short term plasticity.
Author Information (click to view)

McDonnell MD, Graham BP,


McDonnell MD, Graham BP, (click to view)

McDonnell MD, Graham BP,

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PLoS computational biology 2017 09 2213(9) e1005634 doi 10.1371/journal.pcbi.1005634
Abstract

In the brain, the postsynaptic response of a neuron to time-varying inputs is determined by the interaction of presynaptic spike times with the short-term dynamics of each synapse. For a neuron driven by stochastic synapses, synaptic depression results in a quite different postsynaptic response to a large population input depending on how correlated in time the spikes across individual synapses are. Here we show using both simulations and mathematical analysis that not only the rate but the phase of the postsynaptic response to a rhythmic population input varies as a function of synaptic dynamics and synaptic configuration. Resultant phase leads may compensate for transmission delays and be predictive of rhythmic changes. This could be particularly important for sensory processing and motor rhythm generation in the nervous system.

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