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Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan.

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan.
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Wen HJ, Chen CC, Wu MT, Chen ML, Sun CW, Wu WC, Huang IW, Huang PC, Yu TY, Hsiung CA, Wang SL, ,


Wen HJ, Chen CC, Wu MT, Chen ML, Sun CW, Wu WC, Huang IW, Huang PC, Yu TY, Hsiung CA, Wang SL, , (click to view)

Wen HJ, Chen CC, Wu MT, Chen ML, Sun CW, Wu WC, Huang IW, Huang PC, Yu TY, Hsiung CA, Wang SL, ,

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PloS one 2017 04 1412(4) e0175536 doi 10.1371/journal.pone.0175536
Abstract
BACKGROUND
In May 2011, a major incident involving phthalates-contaminated foodstuffs occurred in Taiwan. Di-(2-ethylhexyl) phthalate (DEHP) was added to foodstuffs, mainly juice, jelly, tea, sports drink, and dietary supplements. Concerns arose that normal pubertal development, especially reproductive hormone regulation in children, could be disrupted by DEHP exposure.

OBJECTIVE
To investigate the association between phthalate exposure and reproductive hormone levels among children following potential exposure to phthalate-tainted foodstuffs.

METHODS
A total of 239 children aged <12 years old were recruited from 3 hospitals in north, central, and south Taiwan after the episode. Structured questionnaires were used to collect the frequency and quantity of exposures to 5 categories of phthalate-contaminated foodstuffs to assess phthalate exposure in children. Urine samples were collected for the measurement of phthalate metabolites. The estimated daily intake of DEHP exposure at the time of the contamination incident occurred was calculated using both questionnaire data and urinary DEHP metabolite concentrations. Multiple regression analyses were applied to assess associations between phthalate exposure and reproductive hormone levels in children. RESULTS
After excluding children with missing data regarding exposure levels and hormone concentrations and girls with menstruation, 222 children were included in the statistical analyses. After adjustment for age and birth weight, girls with above median levels of urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and sum of mono-(2-ethylhexyl) phthalate concentrations had higher odds of above median follicle-stimulating hormone concentrations. Girls with above median estimated average daily DEHP exposures following the contamination episode also had higher odds of sex hormone-binding globulin above median levels.

CONCLUSIONS
Phthalate exposure was associated with alterations of reproductive hormone levels in girls.

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