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Physiological and pharmacological inductors of HSP70 enhance the anti-oxidative defense mechanisms of the liver and pancreas in diabetic rats.

Physiological and pharmacological inductors of HSP70 enhance the anti-oxidative defense mechanisms of the liver and pancreas in diabetic rats.
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Dimitrovska M, Dervisevik M, Cipanovska N, Gerazova K, Dinevska-Kjovkarovska S, Miova B,


Dimitrovska M, Dervisevik M, Cipanovska N, Gerazova K, Dinevska-Kjovkarovska S, Miova B, (click to view)

Dimitrovska M, Dervisevik M, Cipanovska N, Gerazova K, Dinevska-Kjovkarovska S, Miova B,

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Canadian journal of physiology and pharmacology 2017 10 13() doi 10.1139/cjpp-2017-0394
Abstract

Heat preconditioning (HP) is a powerful adaptive and protective phenomenon and the heat stress proteins (HSPs) it produces are an important determinant for the development of diabetic complications. Aspirin has been reported to modulate heat shock response in different organisms through increased induction of HSPs and is also known to exert anti-oxidative and radical scavenging effects in diabetes. We estimated the effect of physiological [heat stress (HS), 45min / 41±0.5ºC)] and pharmacological (aspirin treatment) induction of HSP70 on several parameters of oxidative state in the pancreas and liver of diabetic rats. Diabetes increased HSP70 level and decreased PARP, glutathione (GSH) and glutathione peroxidase (GPx) activities in pancreas. In liver there was reduction of HSP70 level, GSH concentration and CAT activity, while GPx and GR activity were enhanced. Heat preconditioning of diabetic rats caused an additional increase of HSP70, GSH and antioxidant enzymes in both organs. Pre-treatment of HP-diabetic animals with aspirin led to an additional increase of PARP and HSP70. In conclusion, both HP and aspirin, as physiological and pharmacological inductors of HSP70, respectively, enhance the anti-oxidative defense mechanisms of the liver and pancreas in diabetic rats.

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