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PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo.

PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo.
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Jiang Y, Hao S, Tian W, Gao B, Zhang X, Zhang S, Guo L, Yan J, Luo D,


Jiang Y, Hao S, Tian W, Gao B, Zhang X, Zhang S, Guo L, Yan J, Luo D, (click to view)

Jiang Y, Hao S, Tian W, Gao B, Zhang X, Zhang S, Guo L, Yan J, Luo D,

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Journal of cellular biochemistry 2017 12 13() doi 10.1002/jcb.26604

Abstract

Thyroid cancer is currently the most common endocrine malignancies, and PI3K/Akt pathway play an important role during its initiation and development. IC87114 is an inhibitor of PI3K/Akt pathway. Little is known about the role of IC87114 in the initiation and progression of thyroid cancer. Here, we demonstrated that IC87114 significantly inhibited both the migration and invasion of thyroid cancer cells, which can be mediateded by inhibition of PI3K/Akt pathway.These results suggest that application of IC87114 may prove to be a particularly effective treatment for thyroid cancer. This article is protected by copyright. All rights reserved.

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