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Plasma interleukin-22 levels are associated with prediabetes and type 2 diabetes in the Han Chinese population.

Plasma interleukin-22 levels are associated with prediabetes and type 2 diabetes in the Han Chinese population.
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Shen J, Fang Y, Zhu H, Ge W,


Shen J, Fang Y, Zhu H, Ge W, (click to view)

Shen J, Fang Y, Zhu H, Ge W,

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Journal of diabetes investigation 2017 02 07() doi 10.1111/jdi.12640
Abstract
AIMS
The objective of this study was to investigate the relations between plasma interleukin-22 (IL-22) levels and prediabetes or Type 2 diabetes (T2DM) and search the relevance between plasma concentrations of IL-22 and selected diabetes risk factors in Chinese people.

MATERIALS AND METHODS
The Han Chinese origin men and women subjects were recruited in our study during a conventional medical checkup. Fasting plasma IL-22 levels were detected by ELISA and their relevance with selected diabetes risk factors was explored. Multiple logistic regression analysis was carried out to assess the odds ratio of IFG and T2DM according to plasma IL-22 level.

RESULTS
Compared with NG subjects (250 pg/mL (154-901)), the plasma IL-22 levels in IFG cases (185 pg/mL (145-414)) and T2DM cases (162 pg/mL (128-266)) were significantly lower (respectively, P <0.05, P <0.001). Correlation analysis showed that plasma concentrations of IL-22 were negatively associated with some diabetes risk factors, including body mass index, glucose, systolic blood pressure, diastolic blood pressure and triglyceride. Moreover, the plasma concentrations of IL-22 exhibited a highly significant association with IFG and T2DM. CONCLUSIONS
In Chinese subjects, the plasma concentration of IL-22 is profoundly associated with susceptibility to IFG and T2DM, and Decreased plasma interleukin-22 level is a potential trigger of IFG and T2DM. This article is protected by copyright. All rights reserved.

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