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Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients.

Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients.
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Sone K, Muramatsu H, Nakao M, Kagawa Y, Kurokawa R, Sato H, Niimi A,


Sone K, Muramatsu H, Nakao M, Kagawa Y, Kurokawa R, Sato H, Niimi A, (click to view)

Sone K, Muramatsu H, Nakao M, Kagawa Y, Kurokawa R, Sato H, Niimi A,

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Internal medicine (Tokyo, Japan) 2017 11 0157(3) 383-386 doi 10.2169/internalmedicine.8746-16

Abstract

A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL). Despite intensive work-up, we were unable to detect the underlying cause of CD4+ lymphocytopenia; therefore, a final diagnosis of idiopathic CD4+ T-lymphocytopenia was made.

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