This study review focuses on understanding how Porphyria cutanea tarda (PCT) is a heme biosynthesis issue described by photosensitive bullae and skin fragility1. Sclerodermoid changes and dystrophic calcification are phenomenal, happening in 18% and 8% of patients, respectively1. Scarring alopecia in PCT, or alopecia porphyrinica, is once in a while portrayed, with 5 reports to date2,3,4,5,6,7.
A 75-year-elderly person with longstanding facial and scalp fixing and scalp biopsy exhibiting cutaneous sclerosis over-lying dystrophic calcification was recently determined to have fundamental sclerosis (SSc). Antinuclear counter acting agent was positive (1:1280), while anticentromere, Scl-70, and RNA-polymerase-III were negative. Assessment uncovered facial and scalp sclerosis with ectropion (Figure 1) and 2 scalp ulcers with rock-hard calcinotic knobs. There was no edema or sclerosis of the hands/feet, or nailfold changes. He denied Raynaud marvel (RP). PCT was suspected and 24-h pee porphyrins uncovered uroporphyrin 427 nmol/24 h (ordinary < 30), affirming this analysis.
Reference link- https://www.jrheum.org/content/48/1/145