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Portable GMR Handheld Platform for the Detection of Influenza A Virus.

Portable GMR Handheld Platform for the Detection of Influenza A Virus.
Author Information (click to view)

Wu K, Klein T, Krishna VD, Su D, Perez AM, Wang JP,


Wu K, Klein T, Krishna VD, Su D, Perez AM, Wang JP, (click to view)

Wu K, Klein T, Krishna VD, Su D, Perez AM, Wang JP,

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ACS sensors 2017 10 252(11) 1594-1601 doi 10.1021/acssensors.7b00432
Abstract

Influenza A virus (IAV) is a common respiratory pathogen infecting many hosts including humans, pigs (swine influenza virus or SIV), and birds (avian influenza virus or AIV). Monitoring swine and avian influenza viruses in the wild, farms, and live poultry markets is of great significance for human and veterinary public health. A portable, sensitive, and quantitative immunoassay device will be of high demand especially in the rural and resource-limited areas. We report herein our Z-Lab point-of-care (POC) device for sensitive and specific detection of swine influenza viruses with minimum sample handling and laboratory skill requirements. In the present study, a portable and quantitative immunoassay platform based on giant magnetoresistive (GMR) technology is used for the detection of IAV nucleoprotein (NP) and purified H3N2v. Z-Lab displays quantitative results in less than 10 min with sensitivities down to 15 ng/mL and 125 TCID50/mL for IAV nucleoprotein and purified H3N2v, respectively. This platform allows lab-testing to be performed outdoors and opens up the applications of immunoassays in nonclinical settings.

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