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Postoperative Serum Albumin is a Potential Prognostic Factor for Older Patients with Gastric Cancer.

Postoperative Serum Albumin is a Potential Prognostic Factor for Older Patients with Gastric Cancer.
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Saito H, Kono Y, Murakami Y, Shishido Y, Kuroda H, Matsunaga T, Fukumoto Y, Osaki T, Ashida K, Fujiwara Y,


Saito H, Kono Y, Murakami Y, Shishido Y, Kuroda H, Matsunaga T, Fukumoto Y, Osaki T, Ashida K, Fujiwara Y, (click to view)

Saito H, Kono Y, Murakami Y, Shishido Y, Kuroda H, Matsunaga T, Fukumoto Y, Osaki T, Ashida K, Fujiwara Y,

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Yonago acta medica 2018 03 2861(1) 72-78

Abstract
Background
The incidence of gastric cancer (GC) among older adults is increasing. Therefore, determining postoperative age-associated prognostic factors is clinically important. This study retrospectively investigated the prognostic significance of serum albumin level in older GC patients.

Methods
We enrolled 135 patients aged ≥ 75 years, who underwent gastrectomies with histopathological diagnoses of gastric adenocarcinoma.

Results
Preoperative albumin (pre-Alb) levels in patients with advanced GC and stage III/IV GC were significantly lower than those in patients with early GC (= 0.0032) and stage I/II GC (= 0.006), respectively. Postoperative albumin (post-Alb) levels (measured 1 month after surgery) in male patients and in patients with advanced GC were significantly lower than those in female patients (= 0.024) and those with early GC (= 0.044), respectively. Post-Alb levels of patients who died of other diseases were significantly lower than those who were still living (= 0.0004). Prognosis of patients with high post-Alb levels (≥ 4g/dL) was significantly better than that of patients with low post-Alb levels (< 4g/dL;= 0.045); and in multivariate analysis, post-Alb level was an independent prognostic indicator. Conclusion
Post-Alb level is a useful predictive factor for the prognosis of older GC patients. Postoperative nutritional support might help improve the prognosis of older GC patients.

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