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Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells.

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells.
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Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, Valadas E, Sousa AE, Taveira N,


Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, Valadas E, Sousa AE, Taveira N, (click to view)

Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, Valadas E, Sousa AE, Taveira N,

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AIDS (London, England) 31(17) 2431-2433 doi 10.1097/QAD.0000000000001661

Abstract

: Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

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